Flurbiprofen axetil fat emulsion injection

A technology of flurbiprofen axetil and fat emulsion, applied in the fields of emulsion delivery, making medicines into special physical or taking forms, organic active ingredients, etc.

Inactive Publication Date: 2015-04-08
BEIJING LANDAN PHARMA TECH
View PDF3 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant literature reporting that flurbiprofen axetil injection is used for reducing fever

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Flurbiprofen axetil fat emulsion injection
  • Flurbiprofen axetil fat emulsion injection
  • Flurbiprofen axetil fat emulsion injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] prescription:

[0037]

[0038] Process:

[0039] (1) Preparation of water phase: add glycerin to water to dissolve, heat to 70°C, and set aside;

[0040] (2) Preparation of oil phase: Refined soybean oil is heated to 70°C, egg yolk lecithin (80% phosphatidylcholine content, 17% phosphatidylethanolamine content) is added to dissolve respectively, and flurbiprofen axetil is added, stirred to make its dissolution;

[0041] (3) Preparation of colostrum: Add the oil phase of step (2) into the water phase of step (1), at a temperature of 70°C, high-speed shear dispersion, shear speed of 10,000 rpm, and time of 15 minutes, to form colostrum;

[0042] (4) pH value adjustment: quickly cool down the colostrum in step (3) below 30°C, and adjust the pH value to 4.5-6.5 with disodium hydrogen phosphate citric acid buffer solution (the molar ratio of disodium hydrogen phosphate to citric acid is 4:1) ;

[0043] (5) High-pressure homogenization: the colostrum in step (4) is ho...

Embodiment 2

[0047] prescription:

[0048]

[0049] Process:

[0050] (1) Preparation of water phase: add glycerin to water to dissolve, heat to 70°C, and set aside;

[0051] (2) Preparation of oil phase: Refined soybean oil is heated to 70°C, egg yolk lecithin (80% phosphatidylcholine content, 17% phosphatidylethanolamine content) is added to dissolve respectively, and flurbiprofen axetil is added, stirred to make its dissolution;

[0052] (3) Preparation of colostrum: Add the oil phase of step (2) into the water phase of step (1), at a temperature of 70°C, high-speed shear dispersion, shear speed of 10,000 rpm, and time of 15 minutes, to form colostrum;

[0053] (4) pH value adjustment: quickly cool down the colostrum in step (3) below 30°C, and adjust the pH value to 4.5-6.5 with disodium hydrogen phosphate citric acid buffer solution (the molar ratio of disodium hydrogen phosphate to citric acid is 4:1) ;

[0054] (5) High-pressure homogenization: the colostrum in step (4) is ho...

Embodiment 3

[0058] prescription:

[0059]

[0060]

[0061] Process:

[0062] (1) Preparation of water phase: add glycerin to water to dissolve, heat to 70°C, and set aside;

[0063] (2) Preparation of oil phase: Heat soybean oil, olive oil and medium-chain triglycerides to 70°C, add egg yolk lecithin (80% phosphatidylcholine content, 17% phosphatidylethanolamine content) to dissolve, add fluorine Biprofen axetil drug, stir to dissolve;

[0064] (3) Preparation of colostrum: Add the oil phase of step (2) into the water phase of step (1), at a temperature of 70°C, high-speed shear dispersion, shear speed of 10,000 rpm, and time of 15 minutes, to form colostrum;

[0065] (4) pH value adjustment: quickly cool down the colostrum in step (3) below 30°C, and adjust the pH value to 4.5-6.5 with disodium hydrogen phosphate citric acid buffer solution (the molar ratio of disodium hydrogen phosphate to citric acid is 4:1) ;

[0066] (5) High-pressure homogenization: the colostrum in step ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to flurbiprofen axetil fat emulsion injection which comprises flurbiprofen axetil, oil and egg yolk lecithin, wherein the concentration of the flurbiprofen axetil is 0.1-1.0mg / ml. The flurbiprofen axetil fat emulsion injection prepared by the invention can be used for fever abatement of yeast-induced febrile rats.

Description

technical field [0001] The invention relates to a flurbiprofen axetil fat emulsion injection, in particular to a flurbiprofen axetil fat emulsion capable of reducing fever. Background technique [0002] Flurbiprofen axetil, its chemical name is: (±) 2-(2-fluoro-4-biphenyl)propanoic acid-1-acetoxyethyl ester [0003] Its structural formula is: [0004] [0005] Molecular formula: C 19 h 19 FO 4 [0006] Molecular weight: 330.36 [0007] Flurbiprofen axetil is insoluble in water and needs to be prepared as a liquid emulsion suitable for intravenous injection. Flurbiprofen axetil fat emulsion injection (trade name Kaifen) is a preparation based on the research and development of the concept of drug delivery system, which uses fat emulsion as a drug carrier and encapsulates flurbiprofen axetil. The injection is less irritating and relieves pain. It acts quickly. The advantages of flurbiprofen axetil fat emulsion injection mainly include the following aspects: 1) Targe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/192A61P29/00A61J3/00
Inventor 不公告发明人
Owner BEIJING LANDAN PHARMA TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap