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Application of panax japonicus polysaccharide, total saponins of panax japonicus and panax japonicus saponin V

A technology for total saponins of Panax ginseng and polysaccharides of Panax ginseng, which is applied in the field of medicine, can solve problems such as large side effects, and achieve the effects of small side effects, simple ingredients and clear curative effect.

Active Publication Date: 2015-04-08
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Data show that drugs can reduce symptoms, increase exercise capacity, reduce the number and severity of acute attacks, and improve health status and exercise tolerance, but these drugs have serious side effects. Active part, active ingredient or active ingredient with clear curative effect, used for prevention and treatment of COPD

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Extraction, Purification and Preparation of Panax Ginseng Polysaccharide

[0022] Take bamboo ginseng coarse powder, add 10 times the amount of water, soak for 2 hours, decoct and extract for 2 hours, filter to obtain the filtrate. The dregs were decocted and extracted twice with 8 times the amount of water, each time for 1.5 hours, and filtered. The three filtrates were combined and concentrated under reduced pressure to an appropriate volume. Add high-concentration ethanol to the concentrated solution until the ethanol concentration is 65%, place it at room temperature for more than 12 hours, filter, collect the precipitate, repeat alcohol precipitation twice, combine the precipitate, and freeze-dry to obtain Panax ginseng polysaccharide.

Embodiment 2

[0023] Example 2 Extraction, purification and preparation of total saponins of Panax ginseng

[0024] Take the coarse powder of bamboo ginseng, add 10 times the amount of 60% ethanol, soak for 2 hours, extract for 2 hours under reflux in a water bath, filter to obtain the filtrate. The dregs were reflux extracted twice with 8 times the amount of 60% ethanol, each time for 1.5 hours, and filtered. Combine the filtrates for 3 times, recover the ethanol under reduced pressure until there is no alcohol smell, and prepare a solution with a ratio of medicinal material: medicinal solution (g / m1) of 1:2.5. Put it on the HP-400 macroporous resin column that has been treated, and wash it with water and 60% ethanol in sequence. The 60% ethanol eluents were combined, the solvent was recovered to nearly dryness, and the total saponins of Panax ginseng were obtained by freeze-drying.

Embodiment 3

[0025] Example 3 Extraction, purification and preparation of bamboo ginseng saponin V

[0026] Take the coarse powder of bamboo ginseng, add 10 times the amount of 60% ethanol, soak for 2 hours, reflux extraction for 2 hours, filter to obtain the filtrate, and use 8 times the amount of 60% ethanol to reflux extract twice, each After 1.5 hours, filter. Combine the three filtrates, recover ethanol under reduced pressure until there is no alcohol smell, and prepare a solution with a ratio of medicinal material: medicinal solution (g / ml) of 1:2.5. Put it on the HPD-400 macroporous resin column that has been treated, and wash it with water and 60% ethanol in sequence. Combine the 60% ethanol eluents, recover the solvent to nearly dryness, and dry under reduced pressure at 65°C to obtain the total saponins of Panax ginseng. The total saponins of Panax ginseng were purified by HP-20 resin column, 55%~85% ethanol eluate was collected, ethanol was recovered under reduced pressure, an...

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PUM

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Abstract

The invention discloses an application of panax japonicus polysaccharide, total saponins of panax japonicus, panax japonicus saponin V and a composition of panax japonicus polysaccharide and total saponins of panax japonicus in preparation of medicines for preventing and treating chronic obstructive pulmonary disease. The medicine containing the components is less in side effect, is originated from a single plant, is simple in component, and is definite in curative effect for preventing and treating COPD.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to the application of ginseng polysaccharides, total saponins of ginseng and ginseng saponin V in the preparation of medicines. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease characterized by airflow limitation, which is not fully reversible and develops progressively. It is associated with an abnormal inflammatory response to or noxious particles, with a chronic inflammatory response throughout the airways, lung parenchyma, and pulmonary vasculature. COPD mainly involves the lungs, but it can also cause systemic (or extrapulmonary) adverse effects. [0003] COPD is a common chronic disease worldwide and currently ranks fourth in the global cause of death. According to the World Health Organization's prediction, by 2020, COPD will rank fifth in global disease incidence and third in death cause. In recent year...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P11/00A61K31/715A61K31/704
CPCA61K31/704A61K31/715A61K36/258A61K2300/00
Inventor 陈旅翼兰洲
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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