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Micro-molecule polypeptide as well as application and product thereof

A technology of small molecule peptides and active ingredients, applied in the field of biomedicine, can solve problems such as failure and narrow time window, and achieve the effects of improving nervous system symptoms, facilitating transformation and production, and reducing brain damage.

Inactive Publication Date: 2015-04-08
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to safety considerations and the narrow time window of thrombolytic therapy (less than 4.5 hours), most patients can only receive symptomatic and supportive treatment
At present, more than 1,000 small molecule compounds have been developed in the laboratory for the treatment of cerebral ischemia, and about 200 clinical trials have been carried out, but all these methods are facing failure in clinical application

Method used

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  • Micro-molecule polypeptide as well as application and product thereof
  • Micro-molecule polypeptide as well as application and product thereof
  • Micro-molecule polypeptide as well as application and product thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Example 1 Artificial synthesis of small molecular polypeptides provided by the present invention and small molecular polypeptides for comparison

[0035]The small molecule RNA sequence provided by the present invention is shown as SEQ ID NO.1, which was artificially synthesized by Wuhan Baiyixin Biotechnology Co., Ltd. The synthesis report is as follows, and the chromatogram is as follows figure 1 shown.

[0036] Synthetic HPLC report

[0037]

[0038] Table 1

[0039] Processing Channel Description: W2489 ChA 220nm

[0040]

[0041] After synthesis, the purity of the target small molecule peptide is 99%, 5 mg per bottle, in the form of white powder, stored at -20 degrees in the dark, and completely soluble in water. Before use, it is prepared by diluting with sterile saline according to the specified concentration. Before using in cells or animals, preheat in a 37-degree incubator.

[0042] Small molecule polypeptide for control, the sequence is:

[0043] T...

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Abstract

The invention discloses a micro-molecule polypeptide as well as application and a product thereof. The experiment proves that the micro-molecule polypeptide is applied to preparing medicines for reducing neuronal death after ischemia, medicine for reducing neuronal apoptosis after ischemia and medicines for controlling ischemic stroke and has good effects and actual operational feasibility. According to the product provided by the invention, the active ingredients comprise the medicines for controlling ischemic stroke in the micro-molecule polypeptide, and the medicines refer to medically acceptable dosage forms, preferably injections.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically relates to a small molecular polypeptide, its application and products. Background technique [0002] Ischemic stroke is a serious neurological disease caused by the interruption of cerebral blood flow, resulting in thrombosis or embolism, leading to cerebral ischemia. Patients will suffer language impairment, vision loss, paralysis and even death. The morbidity, mortality, and disability rates of stroke remain high. With the aging of the population, the incidence of stroke is still rising. It is recognized as a common refractory disease that seriously endangers human health and life safety. [0003] However, the current treatment options for the damage caused by cerebral ischemia are very limited, and the only effective treatment is thrombolytic therapy using tissue plasminogen activator (tPA). However, due to safety considerations and the narrow time window of thrombolytic the...

Claims

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Application Information

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IPC IPC(8): C07K7/08C12N15/11A61K38/16A61P25/00A61P9/10A61P7/02
Inventor 旺姗裴磊颜欢欢郭豫李浩唐娜庞培鲁友明
Owner HUAZHONG UNIV OF SCI & TECH
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