Effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections

A technology of composition and form, applied in the direction of anti-infective drugs, drug combinations, preparations for in vivo tests, etc., can solve the problems of high microbial mortality and inability to ensure sufficient distribution of microorganisms, etc.

Inactive Publication Date: 2015-04-15
PROBIOTICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Finally, conventional vaginal tablets pose the problem of high microbial mortality during their manufacture, and they do not ensure adequate distribution of microorganisms in the vaginal environment

Method used

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  • Effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections
  • Effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections
  • Effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections

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Embodiment Construction

[0027] In a preferred embodiment, the effervescent composition in solid form is in the form of a tablet, ovule, lozenge or granule.

[0028] The organic acid is selected from the group consisting of (or, alternatively comprising), citric acid, malic acid, tartaric acid, fumaric acid, lactic acid, and mixtures thereof. In a preferred embodiment, the organic acid is citric acid.

[0029] The Applicant has found that the use of adipic acid and / or ascorbic acid as organic acids present in the aforementioned acid-base system causes a toxic effect on microorganisms leading to their death when preparing solid form compositions such as powders or granules. In the case of tablet manufacture, the death occurs after mixing the components to make a solid form composition (eg, powder or granules), but before compression. Accordingly, the compositions of the present invention do not contain adipic acid and / or ascorbic acid.

[0030] The salt of carbonate and / or bicarbonate anion is select...

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Abstract

The present invention relates to an effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections.

Description

technical field [0001] The present invention relates to an effervescent composition in solid form for vaginal application for the treatment of vaginal infections. Background technique [0002] It is well known that the composition of the gut and genitourinary microflora is key to an individual's health and well-being. The vaginal ecosystem consists of epithelial cells connecting the vagina and uterus, glandular cells that secrete into the lumen of the organ, and a complex flora represented by different species of microorganisms. [0003] These microorganisms have the ability to ferment decomposed glycogen derived from the subsomal cells of the rich vaginal mucosa, and thus produce lactic acid, whose ultimate role is to establish and maintain an acidic vaginal environment (pH 4-4.5 under physiological conditions) . [0004] H from lactic acid + Contributes to the formation of hydrogen peroxide. This molecule is toxic to a large number of bacterial species that lack catala...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K35/741A61K35/747A61P15/02A61P31/10A61P31/04A61P33/02A61P31/22
CPCA61K35/742A61K35/747A61K9/2054A61K9/205A61K47/02A61K47/12A61K9/0034A61K9/0007A61P15/02A61P31/04A61P31/10A61P31/22A61P33/02Y02A50/30A61K35/74A61K2121/00
Inventor G·莫格纳G·P·斯特罗兹卢卡·蒙加
Owner PROBIOTICAL
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