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Anti-inflammatory and vascular application of trametes gibbosa sporocarp polysaccharide

A technology of plugging bacteria and entities, applied in the field of medicine, can solve problems such as limited means of inflammation prevention, and achieve the effect of reducing permeability, reducing quantity and increasing quantity

Inactive Publication Date: 2015-04-22
曾丹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Inflammation is a common disease in the human body. Because of its multiple occurrence, it has always been a difficult problem in medical treatment. In particular, other diseases caused by inflammation have attracted more and more attention. However, the current prevention methods for inflammation are relatively limited.

Method used

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Embodiment Construction

[0007] The present invention is further described in detail below, but not as any limitation to the present invention.

[0008] Embodiments of the invention:

[0009] Experimental animals:

[0010] Wistar Rat 100-220g

[0011] Experimental Materials:

[0012] Dried fruiting bodies of Trametes metametae

[0013] experimental method:

[0014] The fruiting bodies of Trametes edematis were crushed, soaked and extracted to obtain the polysaccharide components of 5.4% TG-1 and 1.5% TG-2, and the pleurisy model was induced by carrageenan. Intravenous injection of TG-1 and TG-2 (25mg / kg) into rats

[0015] Experimental results:

[0016] Both polysaccharide fractions TG-1 and TG-2 are dextran with small amounts of other sugars. After intravenous injection of Trametesin in rats, it can strongly inhibit the increase of vascular permeability in the rat pleural effusion model induced by carrageenan, but it does not affect the change of the specific gravity of the effusion. Both can...

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Abstract

The invention discloses anti-inflammatory and vascular application of trametes gibbosa sporocarp polysaccharide, wherein the trametes gibbosa sporocarp polysaccharide contains the components including TG-1 and TG-2, and also contains a little glucan of other sugars. After trametes gibbosa polysaccharide is injected in the vein of a rat, increase of vascular permeability in a rat pleural effusion model induced by carrageenin can be strongly inhibited; change of the specific gravity of hydrops cannot be influenced; the content of total protein in pleural effusion can be obviously reduced by both two reasons; an inflammatory mediate compound induced by carrageenin can be effectively antagonized; the permeability of related small blood vessels can be reduced; simultaneously, the numbers of neutrophile granulocyte and eosinophilic granulocyte in a peripheral hemogram can be increased; the number of lymphocyte in the peripheral hemogram can be reduced; and in addition, the pharmacological effects of trametes gibbosa polysaccharides TG1 and TG2 prove the possible effects in the aspects of stabilizing a vascular wall, particularly endothelial injury caused in a pathological state.

Description

technical field [0001] The invention relates to the anti-inflammation and blood vessel application of Trametes edematum fruiting body polysaccharide, belonging to the technical field of medicine. Background technique [0002] Inflammation is a common disease in the human body. Because of its multiple occurrence, it has always been a difficult problem in medical treatment. In particular, other diseases caused by inflammation have attracted more and more attention. However, the current prevention methods for inflammation are relatively limited. Contents of the invention [0003] The purpose of the present invention is to provide anti-inflammation and blood vessel application method of the polysaccharide of Trametesmetae sporocarpus, which can effectively realize anti-inflammation and blood vessel protection, so as to overcome the deficiencies of the prior art. [0004] Technical scheme of the present invention [0005] Anti-inflammatory and vascular applications of polysacc...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P29/00A61P9/00
CPCA61K31/715
Inventor 曾丹
Owner 曾丹
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