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Method for simultaneously detecting phenol, NNK and benzo-[a]-pyrene in main stream smoke of cigar by using gas chromatography-tandem mass spectrum

A technology of cigarette mainstream smoke and tandem mass spectrometry, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of complicated and time-consuming processing, and achieve the effects of simple sample pretreatment, improved analysis throughput, and good repeatability

Active Publication Date: 2015-04-22
ZHENGZHOU TOBACCO RES INST OF CNTC
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Problems solved by technology

[0004] The object of the present invention is to provide a GC-MS / MS method for simultaneous detection of mainstream cigarette smoke, which requires different methods for the detection of phenol, NNK and benzo[a]pyrene in mainstream cigarette smoke, and the sample pretreatment is cumbersome and time-consuming. Methods for phenol, NNK and benzo[a]pyrene in air

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  • Method for simultaneously detecting phenol, NNK and benzo-[a]-pyrene in main stream smoke of cigar by using gas chromatography-tandem mass spectrum
  • Method for simultaneously detecting phenol, NNK and benzo-[a]-pyrene in main stream smoke of cigar by using gas chromatography-tandem mass spectrum
  • Method for simultaneously detecting phenol, NNK and benzo-[a]-pyrene in main stream smoke of cigar by using gas chromatography-tandem mass spectrum

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Embodiment Construction

[0019] The present invention will be further described below in conjunction with embodiment:

[0020] Equilibrate and extract the samples of the cigarettes to be tested, use a rotary smoking machine to smoke according to the standard conditions specified in YC / T29-1996, and use Cambridge filters to capture the particulate matter in the mainstream smoke of 20 cigarettes.

[0021] Put the Cambridge filter with the particulate phase trapped into a 250 mL ground-mouth Erlenmeyer flask, add 40 mL of methanol, add deuterated phenol (1 mg / mL), deuterated NNK (1 μg / mL), Deuterated benzo[a]pyrene (1 μg / mL) methanol solution 200 μL; ultrasonically extract the Erlenmeyer flask at room temperature for 30 min, take 2 mL of the extract, pass through a 0.22 μm organic phase filter membrane, and use a chromatographic vial Samples were collected for GC-MS / MS analysis.

[0022] GC-MS / MS analysis conditions: chromatographic inlet temperature: 260 ℃; injection volume: 1 μL; injection method: spl...

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Abstract

The invention discloses a method for simultaneously detecting phenol, NNK and benzo-[a]-pyrene in main stream smoke of a cigar by using gas chromatography-tandem mass spectrum. The method is characterized by comprising the following steps: gathering phenol, NNK and benzo-[a]-pyrene in the main stream smoke of the cigar by using a Cambridge filter; extracting the Cambridge filter by using an extracting solution; detecting the extracting solution by adopting gas chromatography-tandem mass spectrum (GC-MS / MS); and measuring the content of phenol, NNK and benzo-[a]-pyrene in the main stream smoke of the cigar. In comparison with an existing assay method for independently assaying phenol, NNK and benzo-[a]-pyrene in the main stream smoke of the cigar, the analysis and assay method disclosed by the invention has the advantages of simplifying the pretreatment of a sample, improving the detection sensitivity, also increasing the analysis and assay flux and being suitable for rapid analysis of large-batch samples.

Description

technical field [0001] The invention belongs to the technical field of cigarette smoke analysis and detection, and in particular relates to a method for simultaneously detecting phenol, NNK and benzo[a]pyrene in mainstream cigarette smoke by gas chromatography-tandem mass spectrometry. Background technique [0002] With the signing and entry into force of the "Framework Convention on Tobacco Control", the "regulation of tobacco product components" and "requirements on the disclosure of tobacco products" in the convention have prompted signatories to formulate regulations on the safety of tobacco products, and more strictly restrict The amount of harmful components released in smoke. In order to achieve objective evaluation and effective control of the harmfulness of cigarette smoke, various research institutions and researchers have proposed their own lists of harmful components in tobacco and smoke. The my country Tobacco Monopoly Administration has determined a list of se...

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Application Information

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IPC IPC(8): G01N30/02
Inventor 崔华鹏刘绍锋陈黎蔡君兰余晶晶赵晓东张晓兵谢复炜刘惠民
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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