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Nano emulsion containing fat-soluble phenanthrenequinone compound

A nanoemulsion and compound technology, which is applied in cosmetics, cosmetic preparations, skin care preparations, etc., can solve the problems that tanshinone has not been widely used, the preparation method of liposome is complicated, and the water solubility of tanshinone is poor, so as to achieve anti-aging cell vitality , good skin from UV damage, enhance the effect of cell vitality

Inactive Publication Date: 2015-04-29
AESTHETIC TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Tanshinone has poor water solubility and is easy to decompose when exposed to light and heat, which limits its application in daily chemical fields such as cosmetics
Through liposome technology, the solubility problem of tanshinone can be solved, but the liposome preparation method is generally complicated, and involves the problem of organic solvent and final removal, so tanshinone has not been widely used in the field of daily chemical industry

Method used

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  • Nano emulsion containing fat-soluble phenanthrenequinone compound
  • Nano emulsion containing fat-soluble phenanthrenequinone compound
  • Nano emulsion containing fat-soluble phenanthrenequinone compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0025] Examples 1-3 are used to illustrate the nanoemulsion containing fat-soluble phenanthrenequinone compound provided by the present invention.

[0026] Nanoemulsions were prepared by the following steps:

[0027] Step 1): Mix phospholipids, caprylic / capric glycerides, polyglyceryl oleate, Tween 80, polyethylene glycol caprylic / capric glycerides, and perform high-speed shearing at 8000 rpm until there is no Obtain a mixture of solids visible to the naked eye; step 2) contact tanshinone with the mixture prepared in step 1), and stir at 200 rpm until the system is clear and transparent; 3) process glycerin, water and the clear and transparent mixture obtained in step 2) Mixing, high-speed shearing at 10,000 rpm to obtain colostrum, high-pressure homogenization at 2,000 bar, and 10 cycles to obtain nanoemulsions 1-3 containing fat-soluble phenanthrene quinone compounds.

[0028]Specifically, in Example 1, in parts by weight, the addition amount of each component is: 1 part of...

Embodiment 4-12

[0032] Examples 4-12 are used to illustrate the sunscreen lotion provided by the present invention.

[0033] According to the content of raw materials provided in Table 1, prepare sunscreen 1-9 through the following steps: heat components B and C to 75°C and mix them uniformly to obtain a mixture, add component D to the mixture under stirring at 3000rpm, and stir After 15 minutes, the temperature of the whole system was lowered to 25°C, and component A was added under the condition of stirring at 600 rpm, and the stirring was continued for 3 minutes to obtain sunscreen lotion 1-9.

[0034] Wherein, the nanoemulsion containing the fat-soluble phenanthrenequinone compound used in Examples 4, 7 and 10 is the nanoemulsion 1 containing the fat-soluble phenanthrenequinone compound prepared in Example 1; used in Examples 5, 8 and 11 The nanoemulsion containing the fat-soluble phenanthrenequinone compound is the nanoemulsion 2 containing the fat-soluble phenanthrenequinone compound pr...

Embodiment 13-15

[0039] Examples 13-15 are used to illustrate the sunscreen gel provided by the present invention.

[0040] According to the content of raw materials provided in Table 2, sunscreen gels 1-3 were prepared through the following steps.

[0041] Heat components B and C to 70°C respectively, mix them, add component D under 3000rpm stirring condition, stir for 15min, then lower the system to 25°C, add component A under 600rpm stirring condition, continue stirring for 3min Get sunscreen gels 1-3. Wherein, the nanoemulsion containing the fat-soluble phenanthrenequinone compound used is the nanoemulsion 1 containing the fat-soluble phenanthrenequinone compound prepared in Example 1.

[0042] Table 2

[0043]

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Abstract

The invention relates to nano emulsion containing a fat-soluble phenanthrenequinone compound. The nano emulsion is prepared from the following raw material components in parts by weight: 0.8-1.2 parts of tanshinone, 1.2-1.6 parts of phospholipid, 12-16 parts of glyceride octoate / sebacate, 0.4-0.6 part of polyglycerin oleate, 0.8-1.2 parts of tween 80, 0.8-1.2 parts of polyethylene glycol glyceride octoate / sebacate, 70-75 parts of glycerol and 5-9 parts of water. The nano emulsion containing the fat-soluble phenanthrenequinone compound provided by the invention has the following advantages that: tanshinone has functions of scavenging free radical and protecting cells from oxygen radical damages, strengthening fibroblast activity and increasing collagen synthesis, so that an ageing process is delayed. The nano emulsion is taken as a carrier of the tanshinone, so that the prepared nano emulsion containing the fat-soluble phenanthrenequinone compound has the advantages of being strong in stability and high in activity; when the nano emulsion is applied to preparing a cosmetic composition, bioactivity of the tanshinone can be brought into play better.

Description

technical field [0001] The invention relates to the field of daily chemical industry, in particular to a nanoemulsion containing fat-soluble phenanthrenequinone compound with sunscreen function and a preparation method thereof. Background technique [0002] Tanshione (Tanshione) is the fat-soluble active ingredient in the traditional Chinese medicine Salvia miltiorrhiza. (GSH-Px) activity is enhanced, SOD activity in the skin is enhanced, and cells clear H 2 o 2 and O2 - Ability to protect cells from free radical damage, and can enhance the activity of fibroblasts, increase collagen synthesis, thereby delaying the aging process; tanshinone has Ca 2+ Antagonist action, which prevents Ca 2+ It enters the cells, inhibits the conversion of xanthine dehydrogenase to xanthine oxidase, and reduces the production of free radicals; in addition, tanshinone has a slight estrogen effect, which can also improve skin aging. [0003] Tanshinone has poor water solubility and is easy to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/63A61K8/84A61K8/85A61K8/04A61Q17/04A61Q19/08
Inventor 陈光张蝶郭玉龙
Owner AESTHETIC TECH BEIJING
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