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A kind of tablet containing metoprolol succinate and preparation method thereof

A technology of metoprolol succinate and tablets, which is applied in the field of medicine, can solve the problems of large differences in drug release curves, and achieve the effects of low cost, reduced drug burden, and low price

Active Publication Date: 2017-06-20
华益泰康药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the sustained-release tablet has a good sustained-release effect and can release the active drug stably, its drug release curve is quite different from that of the original drug

Method used

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  • A kind of tablet containing metoprolol succinate and preparation method thereof
  • A kind of tablet containing metoprolol succinate and preparation method thereof
  • A kind of tablet containing metoprolol succinate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Prescription (9000 tablets). See Table 1.

[0041] Table 1 Prescription

[0042]

[0043]

[0044] (2) Preparation method

[0045] To prepare medicated pellets:

[0046] Take an appropriate amount of water in a beaker, heat it to 70-80°C, add HPMC E5 into the water and stir to disperse it. After cooling down, wait for the HPMC E5 to completely dissolve. Add metoprolol succinate and microcrystalline cellulose PH101, place it in a wet granulator, set the speed of the stirring blade at 200-250 rpm, and the speed of the cutting knife at 2000-3000 rpm, and slowly add the bonding agent after dry mixing. agent solution to make soft material.

[0047] The prepared soft material was transferred to an extruder and extruded into strips with a diameter of 0.4 mm, and the screw speed of the extruder was 50 rpm. Transfer the extruded strips to a spheronizer for spheronization, set the spheronization rate to 1500 rpm, and spheronize for 50 seconds. The spheroidized dr...

Embodiment 2

[0066] (1) Prescription (9000 tablets). See Table 2.

[0067] Table 2 Prescription

[0068]

[0069]

[0070] (2) Preparation method

[0071] To prepare medicated pellets:

[0072] Take an appropriate amount of water in a beaker, heat it to 70-80°C, add HPMC E5 into the water and stir to disperse it. After cooling down, wait for the HPMC E5 to completely dissolve. Add metoprolol succinate and microcrystalline cellulose PH101, place it in a wet granulator, set the speed of the stirring blade at 200-250 rpm, and the speed of the cutting knife at 2000-3000 rpm, and slowly add the bonding agent after dry mixing. agent solution to make soft material.

[0073] The prepared soft material was transferred to an extruder and extruded into strips with a diameter of 0.4 mm, and the screw speed of the extruder was 50 rpm. Transfer the extruded strips to a spheronizer for spheronization, set the spheronization rate to 1500 rpm, and spheronize for 50 seconds. The spheroidized dr...

Embodiment 3

[0092] (1) Prescription (9000 tablets). See Table 3.

[0093] Table 3 Prescription

[0094]

[0095] (2) Preparation method

[0096] To prepare medicated pellets:

[0097]Take an appropriate amount of water in a beaker, heat it to 70-80°C, add polyvinylpyrrolidone into the water and stir to disperse it. After cooling down, wait for the polyvinylpyrrolidone to dissolve completely. Add metoprolol succinate and microcrystalline cellulose, place it in a wet granulator, set the speed of the stirring blade at 200-250 rpm, and the speed of the cutting knife at 2000-3000 rpm, and slowly add the binder after dry mixing The solution is made into a soft material.

[0098] The prepared soft material was transferred to an extruder and extruded into strips with a diameter of 0.4 mm, and the screw speed of the extruder was 50 rpm. Transfer the extruded strips to a spheronizer for spheronization, set the spheronization rate to 1500 rpm, and spheronize for 50 seconds. The spheroidize...

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Abstract

The invention relates to the field of medical technologies, and particularly relates to a metroprolol succinate containing tablet and a preparation method thereof. The tablet is prepared from the following three parts by mixing and pressing: (1) a sustained-release pellet containing part of metroprolol succinate; (2) the rest of the metroprolol succinate; and (3) pharmaceutical excipients, wherein the weight ratio of the part of metroprolol succinate in the sustained-release pellet and the rest of the metroprolol succinate is (6-10):1. Compared with reference listed drugs of metroprolol succinate sustained-release tablets, the tablet disclosed by the invention is low in cost, and good in treatment effect, and can significantly reduce the medication burden.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a tablet containing metoprolol succinate and a preparation method thereof. Background technique [0002] Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. At present, there are more than 160 million hypertensive patients in my country, which seriously threaten people's life and health. Hypertension is a systemic disease characterized by elevated systemic arterial blood pressure, which is caused by the interaction of polygenetic inheritance, environment and various risk factors. β-receptor blockers are widely used as first-line drugs for the treatment of hypertension, which mainly reduce blood pressure by reducing sympathetic nerve activity and autoregulatory mechanism of systemic blood flow. [0003] As the world's first selective β1 receptor blocker, metoprolol was first launched in Europe in 1975. It is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/36A61K31/138A61K31/205A61K47/38A61P9/12
Inventor 诸弘刚何燕妮谭海松周淑清黄茵
Owner 华益泰康药业股份有限公司