Beta-cyclodextrin/amoxicillin inclusion complex, as well as preparation method and application thereof
A technology of amoxicillin and cyclodextrin, which is applied in the directions of active ingredients of heterocyclic compounds, pharmaceutical formulations, medical preparations of non-active ingredients, etc. The content of cillin polymer, reducing the probability of allergic reaction, etc., can improve the phenomenon of deliquescence and agglomeration, expand the scope of clinical use, and improve the palatability.
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[0025] Example 1 Preparation of β-cyclodextrin / amoxicillin inclusion compound and 1% amoxicillin soluble powder
[0026] 1. Weigh 2.8g β-cyclodextrin and add it to 10ml distilled water to make a suspension;
[0027] 2. Add lg amoxicillin and lg micronized silica gel, mix and grind for 3 hours;
[0028] 3. Cool at room temperature, filter, wash the solid with water and dry to obtain β-cyclodextrin / amoxicillin inclusion compound;
[0029] 4. Crush the β-cyclodextrin / amoxicillin inclusion compound through an 80 mesh sieve, and mix it with 95.2g anhydrous glucose to obtain 100g of amoxicillin soluble powder.
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[0030] Example 2 Preparation of β-cyclodextrin / amoxicillin inclusion compound and 20% amoxicillin soluble powder
[0031] 1. Weigh 56g of β-cyclodextrin and add it to 200ml of distilled water to form a suspension;
[0032] 2. Add 20g amoxicillin and 0.2g micronized silica gel, mix and grind for 5 hours;
[0033] 3. Cool at room temperature, filter, wash the solid with water and dry to obtain β-cyclodextrin / amoxicillin inclusion compound;
[0034] 4. Crush the β-cyclodextrin / amoxicillin inclusion compound through an 80-mesh sieve and mix it with 23.8g anhydrous glucose to obtain 100g of amoxicillin soluble powder.
Example Embodiment
[0035] Example 3 Preparation of β-cyclodextrin / amoxicillin inclusion compound and 10% amoxicillin soluble powder
[0036] 1. Weigh 28g of β-cyclodextrin and add it to 100ml of distilled water to form a suspension;
[0037] 2. Add 10g amoxicillin and 0.5g micronized silica gel, mix and grind for 5 hours;
[0038] 3. Cool at room temperature, filter, wash the solid with water and dry to obtain β-cyclodextrin / amoxicillin inclusion compound;
[0039] 4. Crush the β-cyclodextrin / amoxicillin inclusion compound through an 80-mesh sieve, and mix it with 61.5g anhydrous glucose to obtain 100g of amoxicillin soluble powder.
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