Mebendazole composition freeze-dried tablet and preparation method thereof
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A technology of mebendazole and composition is applied in the field of mebendazole composition freeze-dried tablet and its preparation, and achieves the effects of improving dissolution rate, large dissolution rate and good formability
Inactive Publication Date: 2015-05-06
HAINAN WEI KANG PHARMA QIANSHAN
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[0008] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is
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[0026] Example 1
[0027]
[0028] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V) cornstarch solution.
[0029] B. Measure 45ml of purified water, boil it, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.
[0030] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.
[0031] D. Weigh 100 g of mebendazole, add it into 1 L of corn-sucrose solution, and stir for 30 minutes.
[0032] E. After measuring the content of mebendazole in...
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[0034] Example 2
[0035]
[0036] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 13% (W / V) cornstarch solution.
[0037] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.
[0038] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.
[0039] D, take by weighing 100 grams of mebendazole (calculated as 1000 tablets), add 1L of corn-sucrose solution, and stir for 30 minutes.
[0040] E. After measur...
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Abstract
The invention provides a mebendazole composition freeze-dried tablet and a preparation method thereof, and relates to the technical fields of medicines and medicine production. The mebendazole composition freeze-dried tablet comprises mebendazole, starch and sucrose; the starch and the sucrose are taken as auxiliary materials; the common corn starch is subjected to heating process treatment, so that the bonding and disintegration effects of the starch in the tablet can be improved; the moldability of the tablet is improved; the mebendazole composition freeze-dried tablet only needs two auxiliary materials namely the starch and the sucrose; by virtue of a two-dropping and two-rising freeze-drying process, the moldability of the tablet is relatively good by cooling twice and warming twice; and the dissolution rate of the tablet is improved, so that the bioavailability of the tablet is improved. According to the tablet, the defects of a common mebendazole tablet are overcome; the variety and the content of the auxiliary materials in the mebendazole tablet are reduced; the tablet is high in dissolution rate and high in bioavailability; and the curative effect and safety of clinical medication are ensured.
Description
technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a freeze-dried tablet of mebendazole composition and a preparation method thereof. Background technique [0002] Mebendazole is an anthelmintic drug that is effective against various intestinal worms such as roundworms, cockroaches, whipworms, and hookworms, and is the first choice for anti-whipworm drugs. [0003] [0004] Molecular weight: 295.30 [0005] Ordinary mebendazole tablets contain many types and quantities of excipients. Generally, fillers, lubricants, disintegrants, binders, flavoring agents, etc. are used. According to the second part of the Chinese Pharmacopoeia (2010 edition), mebendazole tablets Quality standards, the dissolution rate of mebendazole tablets reaches more than 75% in 120 minutes is qualified, and more and more studies have shown that the toxic and side effects of the excipients themselves, the incompatibility of the ex...
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