Pharmaceutical composition using liensinine to work in coordination with vincristine for chemotherapy and application method of pharmaceutical composition
A technology of vincristine and its application method, which is applied in the direction of drug combination, pharmaceutical formula, antineoplastic drugs, etc., and can solve the problem of few drug combinations
Inactive Publication Date: 2015-05-06
ARMY MEDICAL UNIV
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Problems solved by technology
However, the drug combination itself cannot completely eliminate the problem of drug resistance, so people have been working hard to find more different drug combinations that can be replaced with each other
Regrettably, there are still relatively few drug combinations with vincristine as the main chemotherapy drug
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[0021] 1. A drug combination for chemotherapy with liensinine and vincristine. The drug combination is composed of liensinine injection and chemotherapy drug vincristine injection.
[0022] After knowing that the drug combination provided by the present invention can improve curative effect and reduce adverse reactions, when using the drug combination of the present invention to avoid drug resistance or drug resistance, those skilled in the art are fully capable of targeting specific malignant For tumors, the ratio between the two components of Lianxinine Injection and Vincristine Injection was determined only through limited routine tests. For the several malignant tumor cells selected when the present invention is doing experimental verification, it is advisable for the drug combination to adopt such a proportioning, the actual dose in the liensinine injection: the actual dose in the vincristine injection= 4.88 mg: 0.002857 mg.
[0023] Two, the application method of the me...
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The invention relates to a pharmaceutical composition using liensinine to work in coordination with vincristine for chemotherapy and an application method of the pharmaceutical composition. The pharmaceutical composition comprises a liensinine injection solution and a chemotherapy drug vincristine injection solution. The application method comprises the following steps: (1) performing intravenous injection of liensinine once daily according to the dose that actual dosage in the liensinine injection solution to the body weight of a patient is equal to 4.88mg / kg; (2) performing intravenous injection of vincristine once according to the dose that the actual dosage in the vincristine injection solution to the body weight of the patient is equal to 0.02mg / kg on the day of injecting liensinine according to the step (1); (3) performing intravenous injection of the vincristine injection solution once again according to the dose in the step (2) on the eighth day; and (4) determining whether to circulate according to the method of the steps (1)-(3) or not, the number of circulation times and the intermediate drug withdrawal time from the fifteenth day according to the bearing capacity and the treatment effect of a patient body. Compared with the prior art, in the aspect of inhibiting and killing various malignant tumor cells, the pharmaceutical composition provided by the invention has the advantages of reducing the dosage, shortening the treatment period and reducing the occurrence of toxic and side reactions.
Description
technical field [0001] The present invention relates to the drug combination and specific application method of using other drugs to cooperate with vincristine when treating malignant tumors by means of chemotherapy. Background technique [0002] Chemotherapy is one of the methods for treating malignant tumors (cancer). It uses chemical drugs to prevent the proliferation, invasion, and metastasis of cancer cells, and finally kills cancer cells. Vincristine (Vincristine is one of the chemotherapy drugs in clinical application, its structural formula is: [0003] [0004] Vincristine injection (also known as "injection") is used clinically. In the treatment of acute leukemia, malignant lymphoma, multiple myeloma, breast cancer, osteosarcoma, soft tissue sarcoma and lung cancer, it has a relatively significant effect. However, like other chemotherapeutic drugs, vincristine, due to its poor selectivity to tumor cells, will inevitably damage normal cells of the human body wh...
Claims
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IPC IPC(8): A61K31/475A61P35/00A61P35/02A61K31/4725
Inventor 高宁周静李国兵张宏伟
Owner ARMY MEDICAL UNIV