Method for rapidly and simply preparing uniform and stable pentobarbital sodium solution

A technology of sodium pentobarbital and solution, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of not finding the literature of pentobarbital sodium solution, etc. , to achieve the effect of fast preparation and simple operation

Inactive Publication Date: 2015-05-20
WUXI APPTEC SUZHOU +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Through literature search, there is no literature data that can quickl

Method used

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  • Method for rapidly and simply preparing uniform and stable pentobarbital sodium solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Proceed as follows:

[0050] 1) Weigh 12.08g of sodium pentobarbital (99.3% purity) powder into a 250ml beaker.

[0051] 2) Add 20mL of 95% (volume percentage) ethanol to the container to disperse the sodium pentobarbital powder.

[0052] 3) Add 80mL of propylene glycol to the container, and keep stirring at room temperature until all the sodium pentobarbital powder is wetted and dispersed evenly.

[0053] 4) Dilute to a final volume of 200mL with sterile water for injection.

[0054] 5) Continue to stir at room temperature until a clear and homogeneous solution is formed.

[0055] 6) Filter the solution formed in the above 5) with a 0.22 μm sterile filter into a sterile bottle to obtain a sterilized high-concentration pentobarbital sodium solution (for injection administration), with a concentration of 6g / 100ml .

Embodiment 2～ Embodiment 5

[0057] Except that the type of ethanol and its consumption in Example 1, the consumption of propylene glycol and the concentration of the pentobarbital sodium solution of the final preparation are changed into the composition and consumption as shown in Table 1, other are the same as Embodiment 1, obtain sterilization High concentration pentobarbital sodium solution (for injection).

[0058] The pentobarbital sodium solution (200mL) of table 1 embodiment 2~embodiment 5

[0059]

[0060] NOTE: The final volume in Table 1 is 200 mL

[0061] Pentobarbital sodium solution can be prepared quickly and easily according to the steps in the above examples, which solves the problem of poor preparation effect of high-concentration pentobarbital sodium solution and precipitation during storage, and can be widely used in uniform and stable Preparation of high concentration pentobarbital sodium solution.

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Abstract

The present invention discloses a method for rapidly and simply preparing a uniform and stable pentobarbital sodium solution. The method comprises: (1) dissolving sodium pentobarbital in ethanol and propylene glycol to prepare a pentobarbital sodium mixture; and (2) using sterile water for injection to carry out volume metering, filtering, and sterilizing to form the sodium pentobarbital solution. According to the present invention, the operation is simple, and the preparation is fast; the concentration of the pentobarbital sodium solution prepared through the method of the present invention can be increased by one time, such that the difficult problem of preparation of the uniform and stable high-concentration pentobarbital sodium solution is solved, and the method can be widely used for preparing the uniform and stable high-concentration pentobarbital sodium solution; and the prepared pentobarbital sodium solution does not produce deterioration and precipitate even after long storage.

Description

technical field [0001] The invention relates to a method for preparing a pentobarbital sodium solution, in particular to a method for quickly and easily preparing a uniform and stable pentobarbital sodium solution. Background technique [0002] Pentobarbital sodium is white crystalline granules or white powder, odorless, slightly bitter taste, hygroscopic, easily soluble in water and ethanol, almost insoluble in organic solvents. [0003] Pentobarbital sodium is a barbiturate hypnotic, which has a wide range of inhibitory effects on the central nervous system. It produces sedative, hypnotic and anticonvulsant effects depending on the dosage. When a large dose is used, it produces anesthesia, and the action time can last for 4 to 6 hours. , the effect is faster. Therefore, pentobarbital sodium can be used as a hypnotic and pre-anesthesia administration, and can also be used to treat epilepsy and tetanus convulsions. The mechanism of action is considered to be mainly related...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/515A61K47/10A61P25/20
Inventor 王友红陈秀芳周聪颖赵宗良吴小攀陆佳佳李舒舒路腊梅
Owner WUXI APPTEC SUZHOU
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