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Application of copper-doped gold nanorods in preparation of antitumor drugs

A technology of anti-tumor drugs and gold nanorods, applied in anti-tumor drugs, nanotechnology for materials and surface science, nanotechnology, etc., can solve the problem of large size, low uptake rate of gold nanospheres, weak response characteristics, etc. question

Active Publication Date: 2015-05-20
GUANGZHOU CLUSTERBIOPHOTON TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the uptake rate of cancer cells to gold nanospheres is low, resulting in unsatisfactory killing effect
[0005]Gold Nanorod (Gold Nanorod, GNR) itself is non-toxic, has the characteristics of near-infrared laser response, and can be used for laser thermal treatment of cancer. The disadvantage is that gold nanorods The stick is easy to achieve baseball conversion due to heat, causing its response characteristics to weaken or even disappear with the near-infrared laser
However, the size of gold nanorods transformed into gold nanospheres is too large and has no anti-tumor activity.

Method used

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  • Application of copper-doped gold nanorods in preparation of antitumor drugs
  • Application of copper-doped gold nanorods in preparation of antitumor drugs
  • Application of copper-doped gold nanorods in preparation of antitumor drugs

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Embodiment Construction

[0018] For convenience, in the present invention, copper-doped gold nanorods are abbreviated as copper-doped GNRs.

[0019] Application of copper-doped gold nanorods in the preparation of antitumor drugs.

[0020] In the copper-doped gold nanorods, the mass doping amount of copper is 0.5%-0.01%, further, the mass doping amount of copper is 0.2%-0.05%.

[0021] To facilitate tumor targeting, a tumor-targeting agent was coupled to the copper-doped gold nanorods. The tumor targeting agent is preferably a tumor targeting polypeptide.

[0022] In order to facilitate the uptake of GNRs by cells, the aspect ratio AR of copper-doped gold nanorods is above 1.5. Considering the difficulty of the preparation process, the AR value is preferably 3-8.

[0023] Small-diameter copper-doped GNRs are easier to convert into gold nanospheres under the action of ultrasound. Experimental results show that copper-doped GNRs with a diameter of 20nm or less can be converted into gold nanospheres at...

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Abstract

The invention discloses an application of copper-doped gold nanorods in preparation of antitumor drugs. Studies of inventors show that copper-doped gold nanorods are converted into 2-5nm small-sized gold quantum dots under high-power ultrasound action and then selectively kill tumour cells, therefore, the copper-doped gold nanorods can be used as an online antitumor preparation for treating various cancers and the irradiation time of HIFU (high intensity focused ultrasound) can be shortened.

Description

technical field [0001] The invention relates to a new application of nanometer materials, in particular to the application of copper-doped gold nanorods in the preparation of antitumor drugs. Background technique [0002] Worldwide, cancer has become the "first killer" of human beings. World Health Organization (WHO) statistics (2012) show that cancer causes 8.2 million deaths. Over the next 20 years, it is estimated that cancer cases will rise from 14 million in 2012 to 22 million per year. Every year, more than 1 million cancer patients are newly discovered in my country, which brings a huge burden to patients and society. [0003] At present, the treatment of cancer in modern medicine is mainly surgical treatment combined with radiotherapy and chemotherapy, and some targeted or gene drugs are used at the same time to improve the curative effect in response to traditional Chinese medicine treatment; for localized or early cancer, a considerable part uses laser or ultraso...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/48C09K11/58B82Y20/00B82Y30/00A61P35/00
Inventor 铁绍龙兰胜范海华乐琼梁杰霞刘露
Owner GUANGZHOU CLUSTERBIOPHOTON TECH CO LTD
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