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New application of naphthoquine phosphate

A technology of naphthoquine phosphate and new uses, which is applied in the field of new uses of naphthoquine phosphate, and can solve problems such as research reports on naphthoquine phosphate that have not been seen yet

Active Publication Date: 2015-06-03
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no research report on the antibacterial aspect of naphthoquine phosphate

Method used

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  • New application of naphthoquine phosphate
  • New application of naphthoquine phosphate
  • New application of naphthoquine phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Naphthoquine phosphate antibacterial test

[0025] Experimental materials: (1) Sabouraud dextrose agar medium: used for cultivating skin pathogenic fungi. Produced by Beijing Sanyao Science and Technology Development Company, supervised by China National Institutes for Food and Drug Control, batch number 1309022. Formula (g\L): peptone 10, glucose 40, agar 13, pH 5.6±0.2. Sterilize at 121°C for 30 minutes. (2) Nutrient agar medium: used for culturing bacteria. Produced by Beijing Sanyao Science and Technology Development Company, supervised by China National Institutes for Food and Drug Control, batch number 130401. Formula (g\L): peptone 10, beef extract powder 3, sodium chloride 5, agar 14, pH 7.2±0.2. Sterilize at 121°C for 30 minutes.

[0026] Experimental equipment: water-proof electric heating constant temperature incubator, model: PYX-DHS-40×50, produced by Shanghai Yuejin Medical Devices No. 1 Factory; vertical pressure steam sterilizer, model: L...

Embodiment 2

[0059] Embodiment 2 Naphthoquine Phosphate Pharmacological Test on Animal Models of Related Diseases

[0060] 2.1 The treatment of naphthoquine phosphate to trichophyton infected rabbits

[0061] Experimental animal: rabbit, production license number: SCXK (Dian) 2014-0001

[0062] experimental method:

[0063] (1) Select the rabbits with epidermis infection in the laboratory, take samples from the damaged parts and carry out microbial identification, and finally select the rabbits infected with the same bacteria for the experiment.

[0064] (2) Preparation of the test sample: Weigh 50 mg of naphthoquine phosphate, add 1 ml of PEG-400, and dissolve it by ultrasonic. The final concentration of the drug is 50 mg / ml.

[0065] (3) Animal grouping and drug administration: After microbial identification, 8 rabbits infected with Trichophyton were selected and randomly divided into 2 groups, 4 in each group, which were the drug treatment group and the solvent control group, and 4 ra...

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Abstract

The invention discloses a new application of naphthoquine phosphate and application of the naphthoquine phosphate in preparation of an antibacterial drug. The naphthoquine phosphate has the action of inhibiting hormodendrum compactum, hormodendrum dermatitidis, fonsecaea pedrosoi, microsporum gypseum, stellate thyton mentagrophytes, trichophyton verrucosum, microsporum canis, colon bacillus, staphylococcus albus, ataphylococcus aureus, mycobacterium tuberculosis (M.tuberculosis), mycobacterium smegmatis and staphylococcus epidermidis, has remarkable therapeutic effect on infection of the ataphylococcus aureus, the mycobacterium tuberculosis and trichophyton and is a very potential broad-spectrum antibacterial compound. With the antifungal action and the actions of a common pathogen of the naphthoquine phosphate, a novel broad-spectrum antibiotic drug with the action of resisting the common pathogen and the antifungal action is provided to people.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a new application of naphthoquine phosphate. Background technique [0002] Bacterial infection is an acute systemic infection caused by pathogenic bacteria or opportunistic pathogenic bacteria invading the blood circulation to grow and reproduce, producing toxins and other metabolites. Clinically, it is characterized by chills, high fever, rash, arthralgia, and hepatosplenomegaly. Some may have septic shock and migratory lesions. Clinically, some patients may also experience irritability, cold extremities and cyanosis, thin and rapid pulse, rapid breathing, and decreased blood pressure. Especially the elderly, children, those with chronic diseases or low immune function, those who are not treated in time and have complications may develop sepsis or sepsis. Common clinical antimicrobial treatment plans are formulated or revised according to the type of pathogenic b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4706A61P31/04A61P31/10
CPCA61K9/20A61K31/4706Y02A50/30
Inventor 张建文杨兆祥刘国光王萍
Owner KPC PHARM INC
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