Carvedilol tablet and preparation method thereof

Abstract

The invention discloses a carvedilol tablet and a preparation method thereof and belongs to the field of pharmacy. The carvedilol tablet comprises, by weight, 5-50 parts of carvedilol, 10-30 parts of a filler, 2-10 parts of a surfactant, 2-10 parts of a binder, 5-15 parts of a lubricant and 5-20 parts of a flow aid. The preparation method comprises the following steps of weighing raw material powder according to the above ratio, mixing the carvedilol, filler and surfactant powder to obtain uniform powder, adding the lubricant, binder and flow aid into the mixture, carrying out mixing to obtain a uniform mixture, putting the mixture into a tablet machine, preparing tablets and carrying out packaging. The carvedilol tablet can be dissolved in water easily, is suitable for oral administration, has a fast release rate and produces effects fast. The preparation method has simple processes, can be operated easily and is suitable for batch production.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a carvedilol tablet and a preparation method thereof. Background technique [0002] Carvedilol is an α and β receptor blocker, which can relax blood vessels while blocking receptors. It is used to treat mild and moderate hypertension or hypertensive patients with renal insufficiency and diabetes. Carvedilol is easily absorbed after oral administration, with an absolute bioavailability (F) of about 25% to 35%, a significant first-pass effect, and an elimination phase half-life (t1 / 2b) of about 7 to 10 hours. When taken with food, its absorption is slowed, but has no significant effect on bioavailability, and can reduce the risk of orthostatic hypotension. Carvedilol is a basic lipophilic compound with a binding rate of more than 98% to plasma proteins. Its steady-state volume of distribution is about 1.5L, and its plasma clearance rate is 500-700ml / min. Carvedilol is complet...

AI Technical Summary

Problems solved by technology

[0003] Carvedilol tablets currently used are not easily soluble in water, have a slow onset of action, cannot achieve the effect of rapid drug release, and cannot be quickly absorbed by patients.