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Health product or pharmaceutical composition capable of promoting bone or joint health, and preparation method and application thereof

A technology for health care products and compositions, which can be used in drug combination, food preparation, bone diseases, etc., can solve the problems of high toxicity, adverse reactions, high price, etc., and achieve the effect of improving joint redness, no toxic side effects, and good compatibility.

Inactive Publication Date: 2015-06-17
SICHUAN SAINTHOOD BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of NSAIDs in the first few weeks of the patient's symptoms has a very good effect, but the main function of NSAIDs is to relieve joint pain, swelling and improve joint function in RA patients, it is difficult to prevent the development of the disease, and it cannot prevent the destruction of the joints. have severe gastrointestinal adverse reactions
DMARDs, such as methotrexate, can quickly and persistently inhibit inflammation, but due to high toxicity and high price, the clinical application of these drugs is limited

Method used

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  • Health product or pharmaceutical composition capable of promoting bone or joint health, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Cut into slices or sections with 20kg of cinnamon sticks, 15kg of cassia twig, 20kg of white peony, 20kg of papaya and 20kg of Achyranthes bidentata, wash, add 3 times of 75% ethanol for 4 hours, then add 5 times of 75% ethanol, heat and boil for 2 hours to filter Take the filtrate, add 6 times the amount of 75% ethanol to the filter residue, heat and boil for 1.5 hours, filter the filtrate, combine the two filtrates, concentrate under reduced pressure (density 0.24-0.46g / ml), spray dry to obtain dry extract powder, dry powder yield It was 22.3%.

[0045] Take the extract powder and add an appropriate amount of starch to prepare granules.

Embodiment 2

[0047] Cut into slices or cuts with 10kg of cassia sticks, 5kg of cinnamon sticks, 10kg of white peony, 10kg of papaya and 10kg of Achyranthes bidentata, wash, add 3 times of 75% ethanol for 4 hours, then add 5 times of 75% ethanol, boil for 2 hours and filter Take the filtrate, add 6 times the amount of 75% ethanol to the filter residue, heat and boil for 1.5 hours, then filter the filtrate, combine the two filtrates, concentrate under reduced pressure (density 0.24-0.46g / ml), spray dry to obtain dry extract powder, dry powder yield Is 21.8%.

[0048] Take the extract powder, add appropriate amount of starch and dextrin, granulate, and compress to obtain tablets.

Embodiment 3

[0050] Cut into slices or cuts with 30kg of cassia sticks, 25kg of cassia twig, 30kg of white peony, 30kg of papaya and 30kg of Achyranthes bidentata, wash, add 3 times of 75% ethanol for 4 hours, then add 5 times of 75% ethanol, boil for 2 hours and filter Take the filtrate, add 6 times the amount of 75% ethanol to the filter residue, heat and boil for 1.5 hours, filter the filtrate, combine the two filtrates, concentrate under reduced pressure (density 0.24-0.46g / ml), spray dry to obtain dry extract powder, dry powder yield Is 24.1%.

[0051] Take the extract powder, add an appropriate amount of microcrystalline cellulose, mix, dry, and encapsulate to obtain capsules. Each capsule contains 0.5g of extract powder.

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Abstract

A pharmaceutical or health care product composition comprising a preparation made from the following materials in parts by weight: Radix Angelicae Pubescentis 10-30 parts, Ramulus Cinnamomi 5-25 parts, Radix Paeoniae Alba 10-30 parts, Fructus Chaenomelis 10-30 parts and Radix Achyranthis Bidentatae 10-30 parts; a preparation method therefor and a use thereof. It has been proved that the combination of five raw materials has effect of synergistic interaction. The tests show that the pharmaceutical or the health care product composition is effective in treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis or gouty arthritis, and can significantly improve joint swelling, joint pain caused by sudden drop of temperature, joint stiff, joint deformity, joint sharp pains or labor pains, joint numbness, hyperosteogeny and other symptoms. Said composition has a precise and appropriate compatibility, clear effects, non-toxic side effects and high safety.

Description

Technical field [0001] The invention relates to a health product or medicine for promoting bone or joint health, and a preparation method and application thereof. Background technique [0002] Arthritis is an autoimmune disease characterized by their symptoms such as pain, swelling and stiffness in the joints. The two main types of arthritis in mammals are inflammatory arthritis such as rheumatoid arthritis (RA) and osteoarthritis (OA), one that is often secondary to mechanical stress, aging, dysplasia, and / or Progressive, degenerative loss of damaged cartilage. Symptoms of arthritis are generally related to spinal joints, such as toe stiffness, joint purulent psoriasis, or rheumatoid arthritis. [0003] Rheumatoid arthritis is a systemic autoimmune disease dominated by non-infectious inflammation of joints and surrounding tissues. It is mainly joint synovial disease, which can lead to joint stiffness, deformity and severe dysfunction. Rheumatoid arthritis, also known as rheuma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/732A23L1/29A61P19/02A61P29/00A61P19/06A23L33/00
CPCA61K9/1652A61K9/2059A61K9/4866A61K36/21A61K36/232A61K36/54A61K36/65A61K36/732A61P19/00A61P19/02A61P19/06A61P29/00A61K2300/00
Inventor 罗明锋张弘谭名湘李改丽
Owner SICHUAN SAINTHOOD BIOTECH
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