Preparation method and use of biocompatible temperature-sensitive gel microspheres

Abstract

The invention relates to a preparation method and a use of biocompatible temperature-sensitive gel microspheres. The biocompatible temperature-sensitive gel microsphere comprises a, 1-10wt% of 12-hydroxy stearic acid (HSA) and b, 90-99wt% of plant oil, wherein preferably, the plant oil is edible oil such as soybean oil and peanut oil. The biocompatible temperature-sensitive gel microspheres can load a plurality of substances, can control release of the substances, has good temperature sensitivity at a temperature of 30-70 DEG C, has different phase-transition temperatures, and can satisfy different temperature control demands. The preparation method can adjust reaction conditions according to different demands and prepare microspheres with different particle sizes. The biocompatible temperature-sensitive gel microsphere has good mechanical properties and thermodynamic properties, can bear a certain shearing force and pressure, can retain a stable shape and functions for a long time, contains main ingredients of HAS and plant oil extracted from plants and does not produce toxicity and damage to organisms and environment. The ultrasonic emulsification preparation process has simple processes, is free of other stabilizing agents and has a low cost. The biocompatible temperature-sensitive gel microspheres can be widely used in the field of drug slow release, pesticide slow release, food embedding and anticorrosion paint.

Description

technical field [0001] The invention relates to the preparation and application of gel microspheres, in particular to the preparation and application of biocompatible temperature-sensitive gel microspheres. Background technique [0002] Transportation of hydrophobic drugs (such as rifampin), controlled release of pesticides (such as pyrethroids, etc.), long-term action of moisturizing cosmetic preparations (such as glycerin, etc.), embedding treatment of difficult-to-eat foods (such as fish oil, etc.), As well as anti-oxidation protection of anti-corrosion paints and coatings and small molecule pigments in the printing industry, etc. are all technological issues closely related to the process of embedding and releasing. In many cases, not using the embedding process will lead to problems, such as coagulation of drugs in the body, excessive use of pesticides, poor moisturizing persistence of cosmetics, and rapid oxidative fading of paint-based products. [0003] With the res...

AI Technical Summary

Problems solved by technology

However, core / shell structure microcapsules use protein as the shell layer, which increases the cost of raw materials, and if this type of product is used in the human body, there is a risk of species cross-immunity

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