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Drug composition

A composition and monohydrate technology, applied in the field of medicine, can solve the problems of low dissolution rate, large impact, poor compressibility, etc.

Inactive Publication Date: 2015-06-24
迪嘉药业集团股份有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Due to the large size of the composition of the present invention, the production process and final product are greatly affected by the properties of the main drug, especially the tablets have rough surfaces, poor compressibility and brittleness. The problem of high fragmentation, at the same time, there are also problems of slow dissolution rate and low dissolution rate in tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1. 100g glycyrrhizin monohydrate (D90≤10um), 70g mannitol, 20g microcrystalline cellulose, 1.35g sodium lauryl sulfate, 50g 10% povidone K30 aqueous solution, croscarmellose Sodium 20g, fumed silica 2.62g, magnesium stearate 2.62g. 1000 tablets were prepared according to the preparation method in the technical solution section.

Embodiment 2

[0035] Example 2. 150g of glycyrrhizin monohydrate (D90≤8um), 45g of mannitol, 45g of microcrystalline cellulose, 1.35g of sodium lauryl sulfate, 50g of 10% povidone K30 aqueous solution, croscarmellose Sodium 10g, fumed silica 2.71g, magnesium stearate 2.71g. 1000 tablets were prepared according to the preparation method in the technical solution section.

Embodiment 3

[0036] Example 3, the prescription is the same as that of Example 2, but using 3% hydroxypropyl methylcellulose E5 aqueous solution as the binder. 1000 tablets were prepared according to the preparation method in the technical solution section.

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PUM

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Abstract

The invention provides a drug composition and relates to a preparation composition containing liquiritin monohydrate, belonging to the technical field of drugs. Applications of liquiritin to drugs for resisting myocardial ischemia and reperfusion arrhythmia and resisting myocardial ischemia caused by isoprenaline are disclosed in Chinese patents 200610016770.0 and 200610016771 respectively. Due to technical problems, safe and effective liquiritin preparations suitable for human to take orally have not come out. The invention provides a safe and effective liquiritin oral preparation. The liquiritin composition contains 45-71.1% of liquiritin monohydrate, and when the mass percentage of croscarmellose sodium is 3-9.2%, the mass percentage of water soluble auxiliary materials is 6-35%.

Description

technical field [0001] The invention relates to a preparation composition containing liquiritin monohydrate, which belongs to the technical field of medicine. Background technique [0002] In recent years, cardiovascular and cerebrovascular diseases have become the number one killer threatening the health and longevity of middle-aged and elderly people, and one of the three major causes of death for human beings. Cardiovascular and cerebrovascular diseases require long-term medication. Western medicine always has various side effects, and long-term use will cause certain damage to the human body. Therefore, finding safe and effective drugs for treating cardiovascular and cerebrovascular diseases has become a current research hotspot. [0003] Chinese patent 200610016770.0 discloses the application of liquiritin in anti-myocardial ischemia-reperfusion arrhythmia drugs; 200610016771 discloses the application of liquiritin in anti-isoproterenol-induced myocardial ischemia drug...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K47/38A61P9/00A61P9/10A61P9/06
Inventor 张丽丽许蕾连艳菊
Owner 迪嘉药业集团股份有限公司
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