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Pharmaceutical composition used for treating cardiovascular diseases, and preparation method thereof

A composition and cardiovascular technology, which is applied in cardiovascular system diseases, drug combinations, pharmaceutical formulas, etc., can solve the problems of curative effect impact and low content of Danshensu, improve the clarity of the preparation, reduce the purification process, and lighten the color of the preparation Effect

Inactive Publication Date: 2015-06-24
GUIZHOU JINGFENG INJECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] One of the technical problems to be solved by the present invention is to provide a kind of Danshen Pharmaceutical composition for treating cardiovascular diseases with high ketone content

Method used

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  • Pharmaceutical composition used for treating cardiovascular diseases, and preparation method thereof
  • Pharmaceutical composition used for treating cardiovascular diseases, and preparation method thereof
  • Pharmaceutical composition used for treating cardiovascular diseases, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Hot soaking method: take the medicinal material of Salvia miltiorrhiza, after selection, removal of impurities, and cutting, weigh 100Kg of the net medicinal material, put it into the extraction tank, add purified water 10 times the amount of the medicinal material, and extract by hot soaking (80°C±5°C) for 24 hours, forced reflux while extracting, the extract was filtered, and the filtrate was cooled to room temperature 20°C-25°C. Add clarifier 1.0-1.5g / L (chitosan 1000g, add 1% acetic acid 100000ml, stir and let it stand for 24 hours, spare) after clarification for 24 hours, centrifuge and concentrate, and the concentrate will go through alcohol precipitation once more (alcohol-containing amount up to 80%), 1 time of water sinking, concentrated to a relative density of 1.30 or more. Sampling of the hot dipping liquid was submitted for inspection, and the results are shown in Table 1 below:

[0043] Table 1

[0044]

Embodiment 2

[0048] Hot soaking method: take the medicinal material of Salvia miltiorrhiza, after selection, removal of impurities, and cutting, weigh 100Kg of the net medicinal material, put it into the extraction tank, add purified water 10 times the amount of the medicinal material, and extract by hot soaking (80°C±5°C) for 24 hours, forced reflux while extracting, the extract was filtered, and the filtrate was cooled to room temperature 20°C-25°C. Add clarifier 1.0-1.5g / L (chitosan 1000g, add 1% acetic acid 100000ml, stir and let it stand for 24 hours, spare) after clarification for 24 hours, centrifuge and concentrate, and the concentrate will go through alcohol precipitation once more (alcohol-containing amount up to 80%), 1 time of water sinking, concentrated to a relative density of 1.30 or more. The extract was sampled for inspection, and the results are shown in Table 2 below.

[0049] Table 2

[0050]

Embodiment 3

[0054] Hot soaking method: take the medicinal material of Salvia miltiorrhiza, after selection, removal of impurities, and cutting, weigh 100Kg of the net medicinal material, put it into the extraction tank, add purified water 10 times the amount of the medicinal material, and extract by hot soaking (80°C±5°C) for 24 hours, forced reflux while extracting, the extract was filtered, and the filtrate was cooled to room temperature 20°C-25°C. Add clarifier 1.0-1.5g / L (chitosan 1000g, add 1% acetic acid 100000ml, stir and let it stand for 24 hours, spare) after clarification for 24 hours, centrifuge and concentrate, and the concentrate will go through alcohol precipitation once more (alcohol-containing amount up to 80%), 1 time of water sinking, concentrated to a relative density of 1.30 or more. The extract was sampled for inspection, and the results are shown in Table 3 below.

[0055] table 3

[0056]

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Abstract

The invention discloses a pharmaceutical composition used for treating cardiovascular diseases. The pharmaceutical composition is an injection preparation or a freeze-dried powder injection product prepared from radix salviae miltiorrhizae, ligustrazine hydrochloride, and appropriate auxiliary materials. A preparation method comprises following steps: water is added into radix salviae miltiorrhizae for hot dipping extraction; an obtained extract is filtered, and is mixed with a clarifying agent for clarifying; an obtained clarified liquid is subjected to alcohol precipitation or / and water precipitation, and is subjected to concentration until relative density is higher than 1.30 so as to obtain a radix salviae miltiorrhizae extract; the radix salviae miltiorrhizae extract is uniformly mixed with ligustrazine hydrochloride; and then the auxiliary materials are added so as to obtain the pharmaceutical composition. According to the preparation method, hot dipping extraction is adopted, and the extract is filtered, and is mixed with the clarifying agent so as to obtain the radix salviae miltiorrhizae extract; problems caused by high-temperature decoction refluxing, such as complex purification refining processes, a large amount of impurities, incomplete impurity removing, low finished product extract content, and dark color of obtained preparations, are avoided. The preparation method is capable of reducing purification refining processes of danshensu extraction technology, increasing finished product extract danshensu content, improving preparation clarity, and obtaining preparations with light color, and is suitable for industrialized large-scale production; and operation is simple to realize.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating cardiovascular diseases and a preparation method thereof. Background technique: [0002] Cardiovascular disease is a disease with a high mortality rate. According to the report of the World Health Organization, one in every death in the world dies from cardiovascular disease, and the mortality rate is still increasing. Cardiovascular disease has attracted extensive attention from domestic and foreign medical circles. Therefore it is very important to invent a kind of medicament for the treatment of cardiovascular diseases with definite curative effect, safety and convenience, and little side effect. At present, Danshen Ligustrazine Injection is such a medicine for treating cardiovascular diseases with definite curative effect, safety and convenience, and less side effects. [0003] Danshensu (phenolic aromatic acid compound, brown or ye...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/08A61K9/19A61P9/10A61P9/00A61P25/00A61K31/4965A61K31/192
Inventor 叶湘武马贤鹏余渊冯世民
Owner GUIZHOU JINGFENG INJECTION
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