A cold and hot treatment device for melanoma
A treatment device and technology for melanoma, applied in the field of biomedical engineering, can solve the problems of inability to effectively alleviate the immune suppression microenvironment of the body and limited treatment effect, and achieve the effects of inhibiting distant metastasis, improving survival rate, and improving immune response
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Embodiment 1
[0033] Please refer to figure 1 , the device mainly utilizes the treatment control system to control the alternating use of the cold source and the heat source, so as to achieve tumor ablation and distant metastasis inhibition. The device includes a treatment control system A and a tumor treatment unit B, wherein the treatment control system A is composed of a small industrial computer 1 and a display monitoring module 2, wherein the small industrial computer is integrated with a high-speed data acquisition board for Real-time collection of tissue temperature data and relevant treatment parameter data during the treatment process, and through industrial computer program control, a numerical control signal is generated to control the work of the tumor treatment device; the tumor treatment unit B includes a control circuit 3, a cold source 4, and a heat source 5 , temperature sensor 6, conformal probe 7.
[0034] The treatment control system A in the cold and heat treatment dev...
Embodiment 2
[0038] figure 2 It is a structural schematic diagram of a preferred embodiment of the conformal probe 7 of the present invention. In this preferred embodiment, liquid refrigerant is used for cold therapy, and radio frequency or microwave is used for thermal therapy; the conformal probe has a refrigerant flow channel and a refrigerant The inlet 71 and the refrigerant outlet 72 also have a heat source connection port 73. The inner wall of the conformal probe is made of metal, which can conduct the heat source to the conformal treatment surface 74 (the shape of the conformal treatment surface is not unique, any Any shape suitable for closely fitting the tumor surface can be adopted), meanwhile, the outer wall of the probe is protected by a heat insulating layer 75 made of an insulating material. During cryotherapy, the refrigerant enters the probe through the refrigerant inlet 71, and takes away the heat after heat exchange on the conformal treatment surface 74, and the vaporize...
Embodiment 3
[0040] The cold and heat treatment device of the present invention can efficiently treat melanoma. In this embodiment, the present invention is used to treat melanoma in mice to obtain a good therapeutic effect. The specific experimental process is as follows:
[0041] 1. Materials and Methods
[0042] 1.1 Animals, cell lines and main reagents
[0043] Six to eight-week-old SPF grade C57BL / 6 female mice (Shanghai Slack Animal Center) were reared in cages with independent ventilation boxes, and the light was changed artificially for 12 hours day and night. Mice freely ingested 60Co radiation sterilized feed and high temperature sterilized water. Mouse B16F10 melanoma cells (ATCC) were cultured in a medium supplemented with 10% newborn fetal bovine serum (Hangzhou Sijiqing Co., Ltd.) and double antibodies (100U / mL penicillin, 100g / mL streptomycin) (Shanghai Sangon Biological Engineering Co., Ltd. Technology Services Co., Ltd.) in RPMI1640 medium (Hyclone, USA).
[0044] 1.2 ...
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