Preparation method of imprinted polymers of core-shell type molecules, products of imprinted polymers of core-shell type molecules, and application of products
A technology of molecular imprinting and polymers, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of difficult elution of target molecules, low adsorption capacity, slow mass transfer speed, etc., and the method is simple , the effect of high purity
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Embodiment 1
[0026] Synthesis of Lincomycin A Molecularly Imprinted Polymer
[0027] Step 1: Synthesis of core layer polymer (seed)
[0028] Add NaHCO3 (0.238g); sodium dodecyl sulfate (SDS) (0.228g), distilled water 130mL into a 250mL Erlenmeyer flask, stir slowly, heat the water bath to 90°C, and then add the monomer mixture (MMA 9.27ml; EDMA (0.886ml), N2 to remove O2, initiator ammonium persulfate 0.12g, put into constant temperature water bath shaker, at 250 rpm, 80°C, continue to react for 24h.
[0029] Step 2: Synthesis of core-shell imprinted polymers
[0030] Add 18mL of water and SDS (0.10g) into a 250ml Erlenmeyer flask, then add the monomer mixture (EDMA5.43ml; AM 0.05; template molecule lincomycin 0.365g; seeds 29.04ml; Pore agent cyclohexanol 2ml and dodecanol 1ml), N2 remove O2, add initiator ammonium persulfate 0.10g, in warm water bath shaker, at 250 speed, 60 ℃ after continuous reaction for 24h, take out, ice water cooling , to abort the reaction.
Embodiment 2
[0032] Example of elution of template molecules, wash with acetone and methanol to remove self-polymerized and unreacted monomers; then put the polymer in a mixture of methanol and acetic acid (9:1 by volume) to remove target molecules. Wash with aqueous solution.
Embodiment 3
[0034] Equilibrium binding experiment at room temperature, with lincomycin A as the target, dissolve it in water, prepare 10 concentration points from 0.1-1.0mg / ml, the volume is 10ml, add 50mg polymer, shake at room temperature for 24h , the adsorption capacity of lincomycin A can reach 62.66mg / g.
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