The invention relates to a
semen plantaginis active part and a preparation method thereof, and belongs to the technical field of extracts. The technical problems that in the prior art, chemical components of
semen plantaginis are different in anti-oxidation effect, the direct
oral administration availability is low, and clinical application is restricted are solved. The preparation method of the
semen plantaginis active part comprises the following steps of firstly, mixing semen plantaginis with an
ethanol solution, carrying out wall-breaking crushing, standing, carrying out heating
reflux, and concentrating until the
crude drug amount is 2.5-5.0 g / mL, so as to obtain a concentrated solution; and adsorbing the concentrated solution by using macroporous adsorption resin, washing, eluting byusing an
ethanol solution with the concentration of 15vol%-70vol%, collecting the eluate, concentrating, and freeze-
drying to obtain the active part of the semen plantaginis. According to the preparation method, the active part of the semen plantaginis is separated through a
column chromatography technology, wherein the
elution part of the
ethanol solution with the concentration of 15vol%-70vol%has an anti-oxidation effect, and particularly the
elution part of the ethanol solution with the concentration of 50vol% has the optimal effect.