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Method for purifying glycyrrhetinic acid

A technology of glycyrrhetinic acid and purification method, applied in the direction of steroids, organic chemistry, etc., can solve the problems of long extraction time, low extraction efficiency, unfavorable production arrangement, etc., achieve stable yield, improve extraction efficiency, and high purity Effect

Inactive Publication Date: 2015-08-12
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional reflux method takes a long time to extract, usually 3-4 hours. Although there are fewer impurities, the extraction efficiency is relatively low, which is not conducive to industrial production arrangements.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] First, add 900L of ethanol solvent with a concentration of 90% into the reaction kettle, then add 900kg of glycyrrhetinic acid coarse powder into the reaction kettle, stir, raise the temperature to 60°C and keep it warm for 1 hour to form a solution, and then pass the solution through the plate frame Press the filter to filter, the filtered extract is stored in the receiving tank, the filter residue is returned to the reactor, and then 600L of ethanol solvent with a concentration of 90% is added to the reactor, and the extraction steps are repeated to obtain the secondary extract, and then the The obtained secondary extraction filter residue is returned to the reactor, and then adding 300L of ethanol solvent with a concentration of 90% to the reactor, repeating the extraction steps to obtain three extracts, and merging the extracts;

[0028] Add the above-mentioned extract to the neutralization kettle, then fill the neutralization kettle with liquid ammonia to adjust the...

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PUM

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Abstract

The invention discloses a method for purifying glycyrrhetinic acid. The method comprises the steps: with glycyrrhetinic acid coarse powder as a raw material, extracting, neutralizing, refining, extracting, decoloring, drying, and processing by a single-effect rectification spraying tower and the like to extract glycyrrhetinic acid from glycyrrhetinic acid powder. By utilizing the extracting method, the obtained glycyrrhetinic acid has high purity and stable yield, and the extraction efficiency is greatly improved.

Description

technical field [0001] The invention relates to a method for purifying glycyrrhetinic acid, which belongs to the technical field of chemical purification. Background technique [0002] Glycyrrhetinic acid is mainly extracted from the raw material licorice, which belongs to triterpenoids. The pure product of glycyrrhetinic acid is a white crystal, which is hardly soluble in water and ether, but soluble in hot water, ethanol and acetone. Glycyrrhetinic acid is ammonized on the basis of crude glycyrrhetinic acid to obtain triammonium glycyrrhetinic acid, and then acidified with acetic acid to obtain glycyrrhetinic acid. The pure glycyrrhetinic acid is a white powder with a molecular formula of C42H65NO16 and a molecular weight of It is 839.97, sweet, and its sweetness is equivalent to 300 times that of sucrose. It is jelly-like after being dissolved in water, and soluble in ethanol. [0003] Glycyrrhetinic acid is a high-sweetness, low-calorie, safe and non-toxic sweetener. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00
CPCC07J63/008
Inventor 季浩滕丰琳窦长清
Owner JIANGSU TIANSHENG PHARMA