High-stability near-infrared water-soluble CuS fluorescent quantum dots preparation method

A fluorescent quantum dot, high-stability technology, applied in chemical instruments and methods, luminescent materials, copper sulfide, etc., can solve problems such as long reaction time, and achieve the effects of simple equipment, improved stability, and convenient operation

Active Publication Date: 2015-08-12
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods generally require longer reaction time, higher temperature and pressure, and special reaction devices, and most of the copper sulfide nanomaterials prepared by these methods are solid, and they must be post-treated to have water solubility.

Method used

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  • High-stability near-infrared water-soluble CuS fluorescent quantum dots preparation method
  • High-stability near-infrared water-soluble CuS fluorescent quantum dots preparation method
  • High-stability near-infrared water-soluble CuS fluorescent quantum dots preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Dissolve 0.0979g of N-acetyl-L-cysteine ​​in 100mL of deionized water under nitrogen atmosphere and constant stirring, the solution is colorless, add 3mL of CuCl with a concentration of 0.1mol / L 2 Solution, the solution immediately becomes turbid, after mixing evenly, adjust the pH value of the system to 7 with NaOH solution with a concentration of 1mol / L. During the process of adding NaOH solution dropwise, the solution gradually becomes clear, and then add 1mL of NaOH solution with a concentration of 0.1mol / L Na 2 S solution, the solution immediately turns brownish red, and after full reaction, highly stable near-infrared water-soluble CuS fluorescent quantum dots are obtained, which are immediately sealed and stored away from light.

[0019] (2) The fluorescence spectrum of the highly stable near-infrared water-soluble CuS fluorescent quantum dots prepared in step (1) was tested by a fluorescence spectrophotometer, and the test conditions were: voltage 700V, e...

Embodiment 2

[0022] (1) Under nitrogen environment and constant stirring, add 0.0490g, 0.0979g, 0.1469g, 0.2448g and 0.2937g of N-acetyl-L-cysteine ​​to five cones filled with 100mL deionized water In the shaped bottle, five systems were formed. After they were dissolved, 3 mL of CuCl with a concentration of 0.1 mol / L was added to each system. 2 solution, making N-acetyl-L-cysteine ​​and CuCl in five systems 2 The molar ratios were 1:1, 2:1, 3:1, 5:1, and 6:1, and the solution immediately became turbid. After mixing evenly, adjust the pH values ​​of the five systems with a NaOH solution with a concentration of 1mol / L To 7, in the process of adding NaOH solution dropwise, the solution gradually becomes clear, and then add 1 mL of NaOH with a concentration of 0.1 mol / L to the five systems respectively. 2 S solution, the solution immediately turned brownish red, and after full reaction, five parts of highly stable near-infrared water-soluble CuS fluorescent quantum dots were obtained, whi...

Embodiment 3

[0026] (1) Add 0.0979g of N-acetyl-L-cysteine ​​into eight Erlenmeyer flasks containing 100mL of deionized water under a nitrogen environment and constant stirring. After it dissolves, each system Add 3 mL of CuCl with a concentration of 0.1 mol / L 2 solution, making N-acetyl-L-cysteine ​​and CuCl in the system 2 The molar ratio of the solution is 2:1, the solution becomes turbid immediately, after mixing evenly, adjust the pH values ​​of the eight systems to 6, 7, 8, 9, 10, 11, 12 and 13 respectively with NaOH solution with a concentration of 1mol / L , and then add 1 mL of Na with a concentration of 0.1 mol / L to each of the eight systems 2 S solution, the solution immediately turns brownish red, and after fully reacting, eight parts of highly stable near-infrared water-soluble CuS fluorescent quantum dots are obtained, which are immediately sealed and stored away from light.

[0027] (2) The fluorescence spectrophotometer uses a voltage of 700V, and the excitation slit and...

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Abstract

The invention discloses a high-stability near-infrared water-soluble CuS fluorescent quantum dots preparation method. The method is characterized in that under nitrogen environment and continuously stirring condition, 0.0490g-0.2937g N-acetyl-L cysteine is dissolved in 100mL deionized water, 1-5mL CuC12 solution with concentration of 0.1mol / L is added, uniformly mixed, adjusting pH value of the system by using the NaOH solution with concentration of 1mol / L to 5.5-7.5, adding 0.1mol / L Na2S solution with concentration of 0.5-1.5mL, fully reacting, immediately sealing, and keeping in dark place. The fluorescence intensity is obviously enhanced after placing the fluorescent quantum dots for one day; and the change for fluorescence intensity and fluorescence spectrum shape of the high-stability near-infrared water-soluble CuS fluorescent quantum dots is little. The preparation method has the advantages of simple operation and easy control, and has good application prospect on a cell fluorescence probe and immunization analysis aspect.

Description

technical field [0001] The invention relates to the field of nanomaterial preparation, in particular to a method for preparing highly stable water-soluble near-infrared luminescent CuS fluorescent quantum dots using N-acetyl-L-cysteine ​​as a modifier in a nitrogen environment and a normal temperature water phase . Background technique [0002] As a new type of fluorescent material, quantum dots are widely used in research fields such as biochemistry, molecular biology, genomics, drug screening, and biomacromolecular interactions due to their advantages such as narrow emission, wide excitation, and good biocompatibility. It has great application prospect. At present, the preparation of copper sulfide nanomaterials mainly includes chemical deposition method, sonochemical method, hydrothermal synthesis method and microwave radiation method. These methods generally require longer reaction time, higher temperature and pressure, and special reaction devices, and most of the cop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/58C01G3/12
Inventor 覃爱苗孔德霞杜为林覃凤亮莫荣旺廖雷
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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