Crystal form of diethanolamine salt of thrombopoietin mimic and preparation method thereof

A technology of crystallization and medicine, applied in the crystallization form of diethanolamine salt of thrombopoietin mimic and its preparation field, can solve problems such as easy agglomeration, poor product stability, difficult filtration, etc., and achieve repeatable and controllable production process, Good crystal form stability and stable production process
CN104844582AInactive Publication Date: 2015-08-19JIANGSU HENGRUI MEDICINE CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU HENGRUI MEDICINE CO LTD
Publication Date
2015-08-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a crystal form of a diethanolamine salt of a thrombopoietin mimic and a preparation method thereof. Specifically, the invention relates to a type A crystal of (Z)-5-(2-hydroxy-3-(2-(3-methyl-5-oxo-1-(5,6,7,8-tetralin-2-yl)-1H-pyrazole-4(5H)-idene)hydrazino)phenyl)furan-2-diethanolamine carboxylate (a compound as shown in a formula (I)) and a preparation method thereof. The crystal has an x-ray powder diffraction pattern as shown in a figure 1. The type A crystal of the compound as shown in the formula (I) has good chemical stability and crystal-form stability, uses a crystallization solvent with low toxicity and low residues and can be better applied to clinical treatment.
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Description

technical field

[0001] The present invention relates to (Z)-5-(2-hydroxyl-3-(2-(3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalene-2-yl)- Type A crystal of 1H-pyrazole-4(5H)-ylidene)hydrazino)phenyl)furan-2-carboxylic acid diethanolamine salt and its preparation method. Background technique

[0002] Platelets are cells that play an important role in the process of stopping bleeding and repairing damaged blood vessels. A severe deficiency of platelets, known as thrombocytopenia, can have serious consequences and even death. Thrombocytopenia includes idiopathic thrombocytopenia purpura (ITP), and thrombocytopenia caused by chemotherapy (interferon IFN, heparin, etc.), radiotherapy, bacterial or viral infection (HIV, hepatitis C, etc.) and liver disease.

[0003] Thrombopoietin (TPO) is a hematopoietic growth factor that stimulates platelet production in the body. It can regulate the proliferation, differentiation, and maturation of megakaryocytes by binding to a specific recept...

Claims

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