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Standard color card, production method of standard color card and biological analysis detection set

A standard color card and biological analysis technology, applied in the direction of material excitation analysis, fluorescence/phosphorescence, etc., can solve the problems affecting the consistency and accuracy of the test results, the increase of the deviation of the test results, etc., and achieve high accuracy of test results, Reduced deviation and high accuracy

Active Publication Date: 2015-09-02
宿州量彩纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the process of determining the fluorescence intensity of the bioanalysis detector based on fluorescent materials, the photoelectric sensing device of the bioanalysis detector is affected by the strength of the signal source, the use of environmental factors, etc., and the detector is used for a long time due to equipment wear and tear , Aging leads to an increase in the deviation of the test results
Therefore, if there is no calibration of the bioanalytical detector based on fluorescent materials before the project detection, the consistency and accuracy of the detection results of the bioanalytical detector based on fluorescent materials will be affected

Method used

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  • Standard color card, production method of standard color card and biological analysis detection set
  • Standard color card, production method of standard color card and biological analysis detection set
  • Standard color card, production method of standard color card and biological analysis detection set

Examples

Experimental program
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Effect test

Embodiment 1

[0068] Method for making standard color card for fluorescent immunochromatography quantitative detector:

[0069] Use PVC as the base material. Select the CdSe / ZnS semiconductor nanocrystal material dissolved in the water phase, and prepare 5 mL of standard solutions with concentrations of 0.5 mg / mL and 5 mg / mL respectively. Use a plotter to print the above two standard solutions on the substrate in a linear manner, so as to form two chromogenic layers with gradient changes in luminous intensity on one surface of the substrate, and each chromogenic layer forms parallel intervals on the same surface Arranged in a strip pattern, the bandwidth of each chromophoric layer is 1000 microns. Cut the base material into the size of the fluorescent immunochromatography test strip with a cutting knife, and put it into a plastic casing for packaging.

Embodiment 2

[0071] Preparation method of standard color card for fluorescent immunosorbent assay instrument:

[0072] A 96-well plate nested with PET was selected as the base material. Select the CdSe / ZnS semiconductor nanocrystal material dissolved in the water phase, and prepare 5mL of standard solutions with concentrations of 0.1mg / mL, 0.2mg / mL, 0.5mg / mL, 5mg / mL, and 10mg / mL, respectively. Use a plotter to print the above-mentioned 5 kinds of standard solutions on the 96-well plate in a linear dot-like manner, so as to form 5 chromogenic layers with gradient changes in luminous intensity in the wells of the 96-well plate. Circular patterns arranged in parallel and at intervals are formed in the plate wells of the 96-well plate, and the diameter of each chromogenic layer is 1000 microns. Encapsulate the base material with an encapsulation film.

Embodiment 3

[0074] Method for making standard color card for fluorescent immunochromatography quantitative detector:

[0075] PI polyimide is selected as the base material. Select the CdSe / ZnS semiconductor nanocrystal material dissolved in the organic phase, and prepare 5mL of standard solutions with concentrations of 0.01mg / mL, 0.02mg / mL, 0.05mg / mL, 0.5mg / mL, and 1mg / mL, respectively. Use a plotter to print the above five standard solutions on the substrate in a linear manner, so as to form five chromogenic layers with gradient changes in luminous intensity on one surface, and each chromogenic layer forms a parallel layer on the same surface of the substrate. Strip patterns are arranged at intervals, and the width of each chromophoric layer is 1000 microns. Cut the base material into the size of the fluorescent immunochromatography test strip with a cutting knife, and put it into a plastic casing for packaging.

[0076] see Figure 4 , the standard curve linear relationship is mainly...

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Abstract

The invention provides a standard color card which is used for calibrating a fluorescent material based biological analysis detector. The standard color card comprises a shell with a testing window and a base material encapsulated in the shell, wherein a plurality of color development layers which are arranged linearly and of which the light intensities are changed in a gradient manner are formed on the surface of the base material and correspond to the testing window, each color development layer contains a semiconductor nanocrystalline material. The invention also relates to a production method of the standard color card and a biological analysis detection set provided with the standard color card.

Description

technical field [0001] The invention relates to a standard color card, a method for making the standard color card and a biological analysis detection kit. Background technique [0002] At present, the detection principle of biological analysis detectors based on fluorescent materials is based on the principle of light reflection, usually using a certain wavelength and intensity of light source (such as blue light) to irradiate the markers on the substrate to emit fluorescence, and then through photoelectric sensors. The fluorescent signal reflected on the chromatography test strip is converted into an electrical signal, the fitting curve is drawn, and the area or intensity of the peak of the test value curve is calculated to determine the corresponding fluorescent signal intensity, thereby establishing the relationship between the electrical signal and the concentration of the tested sample . [0003] However, in the process of determining the fluorescence intensity of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
Inventor 恒蔚宏袁航李林松
Owner 宿州量彩纳米科技有限公司