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A kind of preparation method and application of hard acyl glycerol in black wolfberry

A technology of stearyl glycerol and wolfberry black fruit, which is applied in the field of preparation of hard acyl glycerol, can solve the problems that have not been reported in the literature and have not been found, and achieve the effects of low price, high recovery rate, and easy batch preparation

Inactive Publication Date: 2016-08-24
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Modern studies have shown that the chemical components in Lycium barbarum mainly include anthocyanins and aliphatic hydrocarbons. Anthocyanins are well known for their remarkable antioxidant activity. pressure activity) related compounds have not been found
[0003] At present, there is no report on the preparation of aliphatic hydrocarbons from Lycium barbarum. Chinese patents (CN101982192B, CN01912480B and 101991709B) report the enrichment of anthocyanins in Lycium barbarum by alcohol extraction, membrane treatment, and macroporous resin. To obtain large-scale 1-[(12E,16E)-12,16-eicosadienoyl]-2-[(E, E)-7,11-octadecadienoyl from Lycium barbarum There is no literature report on the preparation of ]-3-stearyl glycerol

Method used

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  • A kind of preparation method and application of hard acyl glycerol in black wolfberry
  • A kind of preparation method and application of hard acyl glycerol in black wolfberry
  • A kind of preparation method and application of hard acyl glycerol in black wolfberry

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 A kind of preparation method of hard acyl glycerol in black fruit Lycium barbarum, comprises the following steps:

[0031] ⑴Microporous resin impurity removal:

[0032] Dissolve 1000 g of the dark blue extract-like ethanol extract of Lycium barbarum black fruit prepared by a conventional method with a volume fraction 50% ethanol solution 5 times its mass, and filter to obtain filtrate A, which is separated by a microporous resin column on the filtrate A Use 2 times column volume of 95% ethanol solution and 2 times column volume of 100% acetone solution to carry out step gradient elution, collect the 100% acetone solution eluate, and the 100% acetone solution eluate is decompressed After drying, 266.4 g of crude stearyl glycerol in the form of dark yellow oil was obtained.

[0033] Among them: the ratio of the alcoholic extract of Lycium barbarum to the microporous resin was 1 g: 30 mL.

[0034] The reduced-pressure drying conditions refer to a vacuum degr...

Embodiment 2

[0041] Embodiment 2 A kind of preparation method of hard acyl glycerol in black wolfberry, comprises the following steps:

[0042] ⑴Microporous resin impurity removal:

[0043] Dissolve 5000 g of the dark blue extract-like ethanol extract of Lycium barbarum black fruit prepared by a conventional method with a volume fraction of 70% ethanol solution 10 times its mass, and filter to obtain filtrate A, which is separated by a microporous resin column on the filtrate A Carry out step gradient elution with 3 times column volume of 85% ethanol solution and 5 times column volume of 90% acetone solution successively, collect 90% acetone solution eluate, and the 90% acetone solution eluate is decompressed After drying, 1319.4 g of crude product of stearyl glycerol in the form of dark yellow oil was obtained.

[0044] Among them: the ratio of the alcoholic extract of Lycium barbarum to the microporous resin was 1 g: 30 mL.

[0045] The reduced-pressure drying conditions refer to a vac...

Embodiment 3

[0052] Embodiment 3 A kind of preparation method of hard acyl glycerol in black fruit Lycium barbarum, comprises the following steps:

[0053] ⑴Microporous resin impurity removal:

[0054] Dissolve 3000 g of the dark blue extract-like alcoholic extract of Lycium barbarum black fruit prepared by a conventional method with a volume fraction of 60% ethanol solution that is 8 times its mass, and filter to obtain filtrate A. Use 5 times column volume of 90% ethanol solution, 3 times column volume of 95% acetone solution to carry out step gradient elution, collect 95% acetone solution eluate, and the 95% acetone solution eluate is decompressed After drying, 748.2 g of crude stearyl glycerol was obtained in the form of dark yellow oil.

[0055] Among them: the ratio of the alcoholic extract of Lycium barbarum to the microporous resin was 1 g: 30 mL.

[0056] The reduced-pressure drying conditions refer to a vacuum degree of 0.08 MPa and a temperature of 60 °C.

[0057] ⑵ Silica ge...

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Abstract

The invention relates to a preparation method for stearylglycerol in Lycium ruthenicum Murr. The method comprises the following steps: (1) impurity removal with microporous resin: a step of dissolving extract of Lycium ruthenicum Murr with an ethanol solution, separating the obtained solution by using a microporous resin column, carrying out step gradient elution and subjecting eluate to pressure-reduced drying so as to obtain a crude product of stearylglycerol; and (2) silica gel column chromatography separation: a step of subjecting the crude product of stearylglycerol to silica gel column chromatography separation, carrying out elution, collecting fraction, detecting and collecting fraction with an Rf value of 0.1 to 0.2 by using thin-layer chromatography and subjecting the collected fraction to pressure-reduced drying so as to obtain colorless oily 1-[(12E,16E)-12,16-eicosadienoyl]-2-[(E,E)-7,11-octadecadienoyl]-3-stearylglycerol with purity of greater than 95%. The preparation method is simple and has a high recovery rate; and the prepared 1-[(12E,16E)-12,16-eicosadienoyl]-2-[(E,E)-7,11-octadecadienoyl]-3-stearylglycerol has good blood fat-reducing effect.

Description

technical field [0001] The invention relates to a preparation method of hard acyl glycerol, in particular to a preparation method and application of hard acyl glycerol in black wolfberry. Background technique [0002] Lycium ruthenicum Murr. is a plant of the genus Lycium L. in the Solanaceae family. It is mainly distributed in the Qaidam Basin of the Qinghai-Tibet Plateau. "Records" records: Tibetan medicine uses its ripe fruit as medicine to treat heart fever, heart disease, urethral stones, ringworm and scabies, and bleeding gums. It is used as a nourishing, strong and antihypertensive drug among the people. Modern studies have shown that the chemical components in Lycium barbarum mainly include anthocyanins and aliphatic hydrocarbons. Anthocyanins are well known for their remarkable antioxidant activity. pressure activity) related compounds have not been found. [0003] At present, there is no report on the preparation of aliphatic hydrocarbons from Lycium barbarum. Ch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/587C07C67/48C07C67/56A61K31/231A61P3/06A23L33/105
CPCA23V2002/00C07C67/48C07C67/56C07C69/587A23V2200/3262A23V2250/1942
Inventor 党军张莉王启兰陶燕铎邵赟梅丽娟刘增根岳会兰
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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