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Improvements on tissue sealant for use in non-compressible hemorrhage

A tissue and pressure technology, applied in the field of four-component solutions, can solve problems such as inability to rinse or immediately eliminate, adverse reactions, etc.

Inactive Publication Date: 2015-09-16
乔治 D. 福卢什
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another important limitation is the fact that the glue carried by the brace remains in the body until it biodegrades and cannot be flushed or eliminated immediately after surgery
A third important limitation is the adverse effects caused by the inflammatory response produced by some of the compounds included in the formulation

Method used

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  • Improvements on tissue sealant for use in non-compressible hemorrhage
  • Improvements on tissue sealant for use in non-compressible hemorrhage
  • Improvements on tissue sealant for use in non-compressible hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0069] Step 1. Preparation of neutral A:

[0070] ZnCl in the micromolar range

[0071] MgSO in the millimolar range 4

[0072] Radix Fin Cold Water Fish Gel

[0073] sucrose

[0074] polyvinylpyrrolidone

[0075] h 2 O,

[0076] Stir all contents until homogeneous, and then neutralize the solution to pH 7.1 with NaOH

[0077] Step 2. Preparation of Final Solution A

[0078] Neutral A" (above)

[0079] Carrageenan, Type 2 or alpha-galactosidase degraded very small amounts of carrageenan, or alginate sulfate or hyaluronate or hyaluronic acid

[0080] NaHCO 3

[0081] human serum albumin

[0082] All components are stirred, thereby producing a suspension, which is then homogenized.

[0083] Step 3) Preparation of Solution B

[0084] NaH 2 PO4

[0085] tris hydroxymethyl amino methane

[0086] Carbomer 934

[0087] Step 4) Preparation of Solution C

[0088] A 90-120 mg / ml solution of fibrin monomer in 0.125% ice-cold AcOH (pH 3.4) was prepared by dialysis.

[...

example

[0097] 1. Adhesive and viscoelastic properties: The adhesive properties to vital human tissues and the kinetics of gel polymerization have been tested in in vitro and ex vivo studies.

[0098] 1.1. Adhesive properties

[0099] Adhesion and tensile measurements (intra-tissue adhesion and clot strength) were performed in liver tissue of Sprague-Dawley rats. The liver was chosen because it is the organ most frequently injured in abdominal trauma, followed by the spleen.

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PUM

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Abstract

ClotFoam is a sealant and hemostatic agent for use in cases of non-compressible hemorrhage for moderate to severe bleeding. It can be applied in the operating room through laparoscopic ports, or directly over lacerated tissue in laparotomy procedures or outside the operating room through a mixing needle and / or a spray injection method following intracavitary severe trauma or surgery. Its crosslinking technology generates an adhesive scaffold that carries a fibrin sealant required for hemostasis. Clotfoam produces a foam that spreads throughout a body cavity reaching the lacerated tissue to seal tissue and promote the coagulation cascade. The composition is biocompatible and non-inflammatory. The invention uses fibrin monomer polymerized by a change of pH as active sealing component. The viscoelastic properties of the foam as well as the rapid formation of a fibrin clot ensure that the sealant remains at the site of application without being washed away by blood.

Description

technical field [0001] already with The present invention as Trademark relates generally to adhesive sealant components and hemostats; which can be used to bind or seal tissue in the body without pressure, stitches or fibers. Its adhesive and sealing capabilities result from the viscoelasticity (such as gel strength) and coagulability of the combined fibrin components. The present invention specifically relates to four-component solutions; when applied to tissue, the four-component solutions mix together and then solidify in vivo to bind the tissue to seal the tissue so as to prevent or control Cavity or internal bleeding. This is a modification of the composition disclosed in US Patent No. 8,313,211. Background technique [0002] Trauma is a common cause of morbidity and mortality in the world. More than 40% of trauma cases recognized by hospitals in the United States are caused by traffic accidents. On the battlefield of traditional warfare, bleeding is the leading c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K38/45A61P17/02A61P43/00
CPCA61K38/014A61L24/106A61K38/45A61L24/0031A61K38/363A61L2400/04A61P17/02A61P43/00A61P7/04A61K2300/00
Inventor 乔治·D.·福卢什
Owner 乔治 D. 福卢什
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