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Child-type oral anti-epileptic pharmaceutical gel unit and preparation method thereof

An anti-epileptic drug and anti-epileptic technology, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of taking tablets and capsules, reduce the fear of taking medicine, and facilitate storage and transportation. The effect of overcoming pharyngeal stenosis

Inactive Publication Date: 2015-09-23
黑龙江童医生儿童生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a gel unit for children's oral antiepileptic drugs, which solves the problem in the prior art that children have a narrow throat and are difficult to take tablets and capsules

Method used

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  • Child-type oral anti-epileptic pharmaceutical gel unit and preparation method thereof
  • Child-type oral anti-epileptic pharmaceutical gel unit and preparation method thereof
  • Child-type oral anti-epileptic pharmaceutical gel unit and preparation method thereof

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preparation example Construction

[0033] The invention provides a preparation method of a gel unit for oral antiepileptic drugs for children, which is specifically implemented according to the following steps:

[0034] Step 1. Weighing, weighing the following components: antiepileptic drug 0.1-150g, gel matrix 2-60g, improver 0.5-2g, sweetener 3-500g, fragrance 1-5g, preservative 0.1-1.5 g, pH adjuster 1-20ml, the balance is water, the total amount of the above is 1000ml;

[0035] Step 2. Grinding or pre-preparing the weighed antiepileptic drug, gel matrix, modifier, sweetener, flavoring agent, preservative and pH regulator into a solution;

[0036] Step 3, prepare the gel solution, take the weighed gel matrix, modifier and part of the water, boil and stir to form the gel solution;

[0037] Step 4. Add sweetener while it is hot to dissolve it completely, cool to 60°C, then add anti-epileptic drugs, fragrance, preservative and pH regulator, stir evenly, add the remaining water, and immediately fill the mold to...

Embodiment 1

[0039] Embodiment 1 sodium valproate gel (QQ sugar type)

[0040]

[0041]Preparation method: Weigh the pectin, add deionized water, stir under boiling to fully dissolve the pectin into the pectin solution, and add sucrose while it is hot to completely dissolve it, cool to 60°C, then add sodium valproate and other auxiliary materials, Stir well, add water to 1000ml and fill the mold immediately.

[0042] The moisture permeability rate of the airtight package of present embodiment QQ sugar is less than 200g / (m 2 ·24h), the air permeability is less than 40000cm 3 / (m 2 ·24h), the material is high-density polyethylene (HDPE).

Embodiment 2

[0043] Embodiment 2 magnesium valproate gel (jelly type)

[0044]

[0045]

[0046] Preparation method: Take agar, calcium chloride, add appropriate amount of deionized water, boil and stir to fully swell into a colloidal solution, add sucrose while hot to dissolve it, and cool to 60°C. Magnesium valproate and other ingredients are completely dissolved by adding an appropriate amount of deionized water. Mix the two solutions and stir evenly. Add water to 1000ml and immediately fill the jelly.

[0047] The moisture permeability of the airtight package of the present embodiment jelly is less than 200g / (m 2 ·24h), the air permeability is less than 40000cm 3 / (m 2 ·24h), the material is low-density polyethylene (LDPE).

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Abstract

The invention discloses a child-type oral anti-epileptic pharmaceutical gel unit. Every 1000ml of child-type oral anti-epileptic pharmaceutical gel unit comprises the following components: 0.1-150g of anti-epileptic drug, 2-60g of gel matrix, 0.5-2g of improving agent, 3-500g of sweetening agent, 1-5g of aromatic agent, 0-1.5g of preservative, 0-20ml of pH regulating agent and the balance of water. The invention also discloses a preparation method of the child-type oral anti-epileptic pharmaceutical gel unit. The child-type oral anti-epileptic pharmaceutical gel unit adopts multiple innovations including water-soluble gel matrix and the improving agent with unique proportion and the like, and can be generally used for different gel agent forms such as QQ candies, jellies, smoothies or xerogel.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a gel unit for oral antiepileptic drugs for children, and also relates to a preparation method for the gel unit for oral antiepileptic drugs for children. Background technique [0002] The technical shortcomings of different dosage forms of antiepileptic drugs include: for capsules, when children use less than one capsule, the method of pouring out the medicine in the capsule and taking it with water is often used; for bottled oral liquid or syrup, there is a secondary problem. Or the disadvantages of repeated pollution; for tablets, children have difficulty swallowing, and when the dosage is less than one tablet, it needs to be divided artificially, resulting in inaccurate dosage. Some coated tablets and sustained-release tablets lose their specific functions such as protection, taste masking, controlled release, and isolation after being artifici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/19A61K31/7048A61K31/53A61P25/08
Inventor 王世岭彭项雨姜波刘晓磊王娜
Owner 黑龙江童医生儿童生物制药有限公司
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