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Application of matrine in preparation of anti-rheumatoid arthritis drugs

A rheumatoid and matrine technology, applied in the field of medicine, can solve problems such as no reports of matrine rheumatoid arthritis

Inactive Publication Date: 2015-09-30
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far there is no report on the use of matrine in the treatment of rheumatoid arthritis

Method used

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  • Application of matrine in preparation of anti-rheumatoid arthritis drugs
  • Application of matrine in preparation of anti-rheumatoid arthritis drugs
  • Application of matrine in preparation of anti-rheumatoid arthritis drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Anti-rheumatoid arthritis pharmacodynamic experiment of matrine

[0022] 1.1 Experimental materials

[0023] 40 adult male SD rats (provided by the Experimental Animal Center of the Second Military Medical University) of 180-220 g, ELISA kits for rat serum TNF-α and IL-1 (Sigma, USA). Main instruments: toe volume measuring instrument (YLS-7A, equipment station of Shandong Academy of Medical Sciences), microplate reader (BIO-RAD 550), centrifuge (Labofuge 400R, Heraeus company), electronic balance (FA 110A type, Shanghai Precision Scientific Instruments Ltd).

[0024] 1.2 Experimental modeling and administration

[0025] Before the experiment, 40 rats were weighed, randomly divided into 4 groups according to body weight, 10 rats in each group, free to eat and drink, and to drink water. Divided into blank group, model group, positive drug group and matrine group. Blank group: without any treatment; model group: bovine type II collagen acetic acid solution w...

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PUM

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Abstract

The invention relates to the field of medical technologies, in particular to application of alkaloid compound matrine in preparation of anti-rheumatoid arthritis drugs. According to the invention, a type II collagen induced rat rheumatoid arthritis model proves that matrine can significantly improve the symptoms of rheumatoid arthritis rats and has good anti-rheumatoid arthritis effect. The compound matrine involved in the invention can be used for preparation of anti-rheumatoid arthritis drugs, and provides a new source for seeking safe and effective anti-rheumatoid arthritis drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of matrine, an alkaloid compound, in medicines for preventing or treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is one of the most important diseases that endanger human health at present, and is called "the cancer that never dies". RA is a chronic systemic autoimmune inflammatory disease characterized by multi-joint involvement, synovial inflammation, and bone and cartilage destruction. Its pathogenesis has not yet been fully elucidated. Disorders are closely related (Imboden JB. The immunopathogenesis of rheumatoid arthritis. Annu Rev Pathol Mech Dis 2009, 4:417-434.). The prevalence of RA in my country is about 0.3%-0.4%, and there are about 4 million patients. The disability rate is 60% within 5-10 years of the disease course, and 90% of patients in the late stage lose their social labor force and self-care ability, wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P29/00A61P19/02A23L1/29
Inventor 蒲江郑承剑韩婷张巧艳蒋益萍
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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