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Traditional Chinese medicinal preparation having angiotensin converting enzyme inhibition effect

A kind of technology of angiotensin and traditional Chinese medicine preparation, applied in the field of traditional Chinese medicine preparation

Inactive Publication Date: 2015-09-30
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no literature report on the development of Physcomitrella warmum as a drug, and the effect of Physcomitrella warmum on inhibiting angiotensin converting enzyme

Method used

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  • Traditional Chinese medicinal preparation having angiotensin converting enzyme inhibition effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Extraction Example 1: 1. Moss chinensis (fresh product) for heating, chopped, boiled with water to extract 2 times, 12 times the amount for 2 hours for the first time, 8 times the amount for 1 hour for the second time, combine the extracts, and serve while hot AB-8 macroporous resin column, the temperature of the upper column is not lower than 80°C, the flow rate is 1BV / h (the flow is equivalent to the volume of a resin fluid bed per hour, the same below), after the flavonoids are saturated, wash the column with water, and then use 70 % ethanol aqueous solution was used for elution, the eluate was collected, and the solvent was recovered to a thin paste. After the thin paste is dried, the content of flavonoids in the dry paste is 31.8%. ②Collect water vapor containing volatile oil while boiling in water, separate oil from water after cooling, and take the upper layer of oil to obtain volatile oil.

Embodiment 2

[0018] Extraction Example 2: 1. Moss chinensis (dry product) for heating, chopped, boiled with water to extract 2 times, the first time is 15 times the amount for 2 hours, the second time is 8 times the amount for 1 hour, combine the extracts, and serve while hot AB-8 macroporous resin column, the temperature of the upper column is not lower than 80°C, the flow rate is 1.5BV / h (the flow is equivalent to the volume of a resin fluid bed per hour, the same below), after the flavonoids are saturated, wash the column with water, and then use 80% ethanol aqueous solution was used for elution, the eluate was collected, and the solvent was recovered to a thin paste. After the thin paste is dried, the content of flavonoids in the dry paste is 36.2%. ②Collect water vapor containing volatile oil while boiling in water, separate oil from water after cooling, and take the upper layer of oil to obtain volatile oil.

[0019] Two, the following is the implementation example of preparing the ...

Embodiment 2

[0021] Formulation Example 2: Calculated according to the yield of the effective parts, take the dry paste fine powder of the effective part equivalent to 1000g of Physcomitrella radiata crude drug weighing 22g, volatile oil 9ml; add starch to the dry paste fine powder to a total of 120g, granulate, Spray into the volatile oil, mix well, and press into tablets. The weight of the plain tablet is 0.3g, and each tablet contains 2.5g of the crude drug of Physcomitrella grandiflora. Usage and dosage: 3 times a day, 4-5 tablets each time.

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Abstract

The invention relates to a traditional Chinese medicinal preparation having an angiotensin converting enzyme inhibition effect, and a production method thereof. The production method of the traditional Chinese medicinal preparation comprises the following steps: preparing volatile oil and a high-flavonoid component extract from Rhodobryum giganteum Par used as a raw material, and mixing the volatile oil with the extract through adopting a conventional medicinal preparation formation process to prepare the clinically used oral medicine. A pharmacological experiment result shows that the traditional Chinese medicinal preparation has an angiotensin converting enzyme inhibition effect, and can be used to treat the hypertension disease.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmaceutical engineering, and relates to a traditional Chinese medicine preparation capable of inhibiting angiotensin-converting enzymes, in particular to a traditional Chinese medicine preparation prepared by extracting volatile oil and flavonoids from Physcomitrella chinensis as a raw material and a production method thereof. Background technique [0002] Rhodobryum giganteum (Hook.) Par. is an important medicinal moss plant, which has the effects of nourishing the heart and calming the nerves, clearing the liver and improving eyesight. It is used internally to treat palpitations and neurasthenia; externally used to treat red eyes Swelling and pain; folk for the treatment of high blood pressure and coronary heart disease. [0003] In modern research literature, there are not many records of warm land big leaf fresh, so far there are only about 40 articles, and 4 articles involve the...

Claims

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Application Information

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IPC IPC(8): A61K36/10A61P9/12A61P9/10
Inventor 朱智德李学坚刘布鸣黄艳
Owner GUANGXI UNIV OF CHINESE MEDICINE
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