A traditional Chinese medicine composition with external analgesic effect and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine and its preparation, to achieve the effect of relieving rheumatism

Active Publication Date: 2018-07-13
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing traditional Chinese medicines for external use on the market are still far from the ideal analgesic effect. Therefore, research and development of traditional Chinese medicines for external use with strong analgesic effects, rapid onset of effects, and low side effects are the development direction of new Chinese medicines for external use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of topical plaster:

[0025] Calculated by weight as follows:

[0026] Corydalis: 50g

[0027] Preparation method: (1) Grind borneol into fine powder and set aside. (2) Crush the medicinal material through a No. 1 sieve, add 65% ethanol to soak for 30 minutes at a material-to-liquid ratio of 1:6, reflux at 65°C for 30 minutes, collect the filtrate, and concentrate under reduced pressure to a relative density of 1.07. (3) CMC-Na and tartaric acid were mixed with water and swelled overnight to obtain a transparent and uniform liquid, followed by adding 23mL liquid extract and 0.3g borneol and stirring to obtain phase A. In addition, PAAS, aluminum hydroxide, EDTA and glycerin were mixed and stirred to obtain phase B of the suspension. (4) Then slowly pour phase A into phase B, and with continuous stirring, the matrix will rapidly thicken and harden from liquid. After standing for 4 hours, the particles in the matrix disappeared. At this time, the ...

Embodiment 2

[0029] Preparation of topical plaster:

[0030] Calculated by weight as follows:

[0031] Corydalis: 75g

[0032]Preparation method: (1) Grind borneol into fine powder and set aside. (2) Crush the medicinal material through a No. 1 sieve, add 65% ethanol to soak for 30 minutes at a material-to-liquid ratio of 1:6, reflux at 65°C for 30 minutes, collect the filtrate, and concentrate under reduced pressure to a relative density of 1.07. (3) CMC-Na and tartaric acid were mixed with water and swelled overnight to obtain a transparent and uniform liquid, followed by adding 23mL liquid extract and 0.3g borneol and stirring to obtain phase A. In addition, PAAS, aluminum hydroxide, EDTA and glycerin were mixed and stirred to obtain phase B of the suspension. (4) Then slowly pour phase A into phase B, and with continuous stirring, the matrix will rapidly thicken and harden from liquid. After standing for 4 hours, the particles in the matrix disappeared. At this time, the v...

Embodiment 3

[0034] Preparation of topical plaster:

[0035] Calculated by weight as follows:

[0036] Corydalis: 100g

Qingfengteng: 75g

Summer without: 100g

Ice flakes: 0.3g

Backing layer: non-woven fabric

Cover lining: polyester film

Sodium polyacrylate: 10g

Glycerin: 20g

Sodium carboxymethylcellulose: 1.5g

Aluminum glycylate: 0.25g

Citric acid: 0.5g

Edetate disodium: 0.13g

Water: 70g

[0037] Preparation method: (1) Grind borneol into fine powder and set aside. (2) Crush the medicinal material through a No. 1 sieve, add 65% ethanol to soak for 30 minutes at a material-to-liquid ratio of 1:6, reflux at 65°C for 30 minutes, collect the filtrate, and concentrate under reduced pressure to a relative density of 1.07. (3) CMC-Na and tartaric acid were mixed with water and swelled overnight to obtain a transparent and uniform liquid, followed by adding 23mL liquid extract and 0.3g borneol and stirring to obtai...

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PUM

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Abstract

The invention relates to an analgesic traditional Chinese medicine composition for external use and a preparation method thereof, in particular to an analgesic traditional Chinese medicine composition used in the fields of rheumatism pain, surgical pain (without creating wounds), bruises, dysmenorrhea and the like. The analgesic traditional Chinese medicine composition comprises drugs such as Corydalis Corydalis Corydalis, Corydalis Chinensis, Xia Wu, etc. The combination of these drugs can achieve the effects of promoting blood circulation and dispelling blood stasis, reducing swelling and relieving pain, and expelling wind and dampness. It can be effectively used for rheumatic bone pain, rheumatoid arthritis, frozen shoulder, sprains, contusions, bruises, dysmenorrhea and other diseases to relieve pain. The dosage of each component of the traditional Chinese medicine composition of the present invention has definite analgesic effect within the following dosage ranges: 10-40 parts of Corydalis Corydalis, 10-30 parts of Qingfengteng, 10-40 parts of Xia Wu, and 0.5-5 parts of Borneol. The traditional Chinese medicine composition can be extracted with 60-75% ethanol to obtain extract, and then processed into tincture, spray, ointment, external plaster and other external dosage forms through pharmacy.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and its preparation, and relates to an externally used analgesic Chinese medicine composition and a preparation method thereof, in particular to an externally used Chinese medicine composition for rheumatic pain, traumatic pain relief, dysmenorrhea, bruises and the like and a preparation method thereof. Background technique [0002] More than one-third of the world's population suffers from persistent or recurring pain, costing tens of billions of dollars each year in health care, compensation, and litigation in the United States alone. According to a British survey, about 40% of citizens over the age of 25 suffer from varying degrees of pain every day, of which 30% are 25-35 years old, and as high as 60% are over 75 years old. The Australian community epidemiological study showed that about 18% of residents suffered from persistent pain (3 months in the last 6 months). Many ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P29/00A61P15/00A61K31/045
Inventor 李劲平欧霞
Owner CENT SOUTH UNIV
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