Antibacterial polypeptide conjugate with multiple target points and synthesis method and application of biopolymer of antibacterial polypeptide conjugate

A technology of antibacterial polypeptides and peptide conjugates, applied in the preparation of antibacterial drugs, in the field of antibacterial polypeptide conjugates, can solve the problems of drug resistance and other problems
CN104961801AActive Publication Date: 2015-10-07LANZHOU UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Applications(China)
Current Assignee / Owner
LANZHOU UNIVERSITY
Publication Date
2015-10-07

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Abstract

The invention provides an antibacterial polypeptide conjugate Acr3-NLS (nuclear localization sequence) as well as a bipolymer (Acr3-NLS)2 of the antibacterial polypeptide conjugate, and belongs to the field of medicinal chemistry. The antibacterial polypeptide conjugate Acr3-NLS is formed by connecting acridine molecules to an N end of NLS, and the biopolymer (Acr3-NLS)2 is formed by connecting Acr3-NLS molecules by virtue of a disulfide bond. The activity test shows that the antibacterial activity of the antibacterial polypeptide conjugate Acr3-NLS and (Acr3-NLS)2 is remarkably improved compared with that of the NLS, and the bacteria can be killed by virtue of the action mechanism of multiple target points. The action mechanism of the multiple target points can enable the Acr3-NLS and (Acr3-NLS)2 to kill the traditional antibiotics drug-fastness bacteria; moreover, the bacteria is unlikely to have drug fastness. The Acr3-NLS and (Acr3-NLS)2 as an active ingredient have a potential application value in preparing the antibacterial drugs.
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Description

technical field

[0001] The invention belongs to the field of medicinal chemistry and relates to a multi-target antibacterial polypeptide conjugate; the invention also relates to the application of the antibacterial peptide in preparing antibacterial drugs. Background technique

[0002] In the long river of human development, bacterial infection has claimed the lives of countless people. Since the advent of penicillin, a large number of antibacterial drugs have been emerging, which have played a great role in the treatment of bacterial infection diseases. However, due to the irrational application of antibacterial drugs, bacterial drug resistance occurs frequently, and even the speed of drug resistance tendency far exceeds the speed of antibacterial drug research and development. Antimicrobial resistance has become a serious public health problem worldwide. In particular, the emergence of "super bacteria" has made human beings face the dilemma that no medicine is available....

Claims

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