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Directional orderly mineralized material for tooth enamel and preparation method thereof

A kind of tooth enamel and orderly technology, applied in the direction of dental preparations, dentistry, dental prosthesis, etc., can solve the problems of poor bonding ability of the tooth surface, difficult penetration of remineralization preparations, and short residence time on the tooth surface, achieving Hypoallergenic, good biocompatibility, and simple preparation method

Active Publication Date: 2015-10-21
STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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Problems solved by technology

[0003] In view of this, the present invention aims to propose a material for the directional and ordered mineralization of enamel and its preparation method to solve the problems in the prior art that the remineralization preparation is difficult to penetrate into the deep part; the ability to combine with the surface of the tooth body is poor , the time spent on the tooth surface is very short, etc.

Method used

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  • Directional orderly mineralized material for tooth enamel and preparation method thereof
  • Directional orderly mineralized material for tooth enamel and preparation method thereof
  • Directional orderly mineralized material for tooth enamel and preparation method thereof

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Embodiment 1

[0029] A material for directional and ordered mineralization of tooth enamel, prepared through the following steps,

[0030] 1) Synthesis of carboxymethyl chitosan-alendronate sodium polymer

[0031] Under room temperature and full stirring with a magnetic stirrer, add 100 mg of carboxymethyl chitosan to 20 ml of deionized water, and after it is completely dissolved, add 1-(3-dimethylaminopropyl)-3-ethylcarbodiethylene Amine hydrochloride 20 mg, reacted for 15 min, then added 10 mg of N-hydroxysuccinimide to obtain A solution, after that, added 100 mg of alendronate sodium to A solution, reacted at room temperature and normal pressure for 24 hours, and then the The solution was dialyzed with a dialysis bag with a molecular weight of 3500 for 48 hours to obtain a carboxymethyl chitosan-alendronate sodium polymer solution.

[0032] 2) Formation of nano-amorphous calcium phosphate particles

[0033] Under normal temperature and sufficient stirring with a magnetic stirrer, 6.96 ...

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Abstract

The invention provides a directional orderly mineralized material for tooth enamel and a preparation method thereof; after carboxymethyl chitosan and alendronate sodium are crosslinked, a solution containing hydrogen phosphate ions and a solution containing calcium ions are successively dropwise added, then nano amorphous calcium phosphate particles are formed, followed by, glutamic acid is added to the solution, and thus the mineralized material is obtained. The mineralized material is simple and convenient in preparation method, can be permeated to below a demineralization surface to reach deep mineralization, and is fixedly combined with a tooth body surface; newly formed hydroxyapatite is in directional orderly arrangement, and is similar to natural tooth enamel; the mineralized material has the advantages of no toxicity, no stimulation, good biocompatibility, low sensitization, and ideal use effect.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a material for directional and ordered mineralization of tooth enamel and a preparation method thereof. Background technique [0002] At present, common remineralization preparations mainly use mineral ions such as calcium and phosphate as active ingredients, supplemented with fluoride ions or other substances, so as to achieve the purpose of mineral reconstruction on the residual crystals on the surface of demineralized caries lesions. However, traditional remineralization agents have certain limitations. For example: it can only achieve the remineralization of the demineralized surface layer, and it is difficult to penetrate into the deep part; it has poor binding ability with the tooth surface, it is difficult to resist the erosion of saliva, and it stays on the tooth surface for a short time; The fluorine preparations in the field can easily cause chronic fl...

Claims

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Application Information

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IPC IPC(8): A61K6/097A61K6/033A61K6/838A61K6/898
Inventor 张旭王浩荣
Owner STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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