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Recombinant human basic fibroblast growth factor gel without bacteriostatic agent and preparation method thereof

A fibroblast and growth factor technology, applied in the field of recombinant human basic fibroblast growth factor gel and its preparation, can solve problems such as adverse reactions and achieve the effect of avoiding stimulation

Inactive Publication Date: 2015-10-21
ZHUHAI ESSEX BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although bacteriostatic agents have positive significance in preventing microbial contamination, they can also cause many adverse reactions

Method used

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  • Recombinant human basic fibroblast growth factor gel without bacteriostatic agent and preparation method thereof
  • Recombinant human basic fibroblast growth factor gel without bacteriostatic agent and preparation method thereof
  • Recombinant human basic fibroblast growth factor gel without bacteriostatic agent and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0022] The embodiment of the present invention provides a recombinant human basic fibroblast growth factor gel that does not contain bacteriostatic agents, including the following components: recombinant human basic fibroblast growth factor 1×10 6 IU, mannitol 0.01g, polyvinyl alcohol 0.1g, sodium hydroxide 0.1g, phosphate buffered saline 0.1g, glycerol 0.1g, add water for injection to make up to 1000ml.

[0023] The embodiment of the present invention also provides a preparation method of recombinant human basic fibroblast growth factor gel without bacteriostatic agent, comprising the following steps:

[0024] S1: Weigh 0.1 g of polyvinyl alcohol, dissolve 0.1 g of sodium hydroxide in water for injection, and sterilize by autoclaving at 121°C for 30 minutes;

[0025] S2: Weigh recombinant human basic fibroblast growth factor 1×10 6 IU, mannitol 0.01g, phosphate buffer 0.1g, glycerin 0.1g were dissolved in water for injection;

[0026] S3: Filter the medicinal solution obtai...

Embodiment 2

[0029] The embodiment of the present invention provides a recombinant human basic fibroblast growth factor gel that does not contain bacteriostatic agents, including the following components: recombinant human basic fibroblast growth factor 9×10 6 IU, sodium lauryl sulfate 5.0g, carboxymethylcellulose 20.0g, sodium carbonate 10.0g, sodium citrate / citrate buffer pair 10.0g, propylene glycol 50g, add water for injection to make up to 1000ml.

[0030] The preparation method of the bacteriostatic-free recombinant human basic fibroblast growth factor gel provided in this example is the same as that in Example 1.

Embodiment 3

[0032] The embodiment of the present invention provides a recombinant human basic fibroblast growth factor gel that does not contain bacteriostatic agents, including the following components: recombinant human basic fibroblast growth factor 6×10 6 IU, hyaluronic acid 1g, sodium alginate 3g, disodium hydrogen phosphate 2.5g, phosphate buffered saline 1.5g, glycerin 30g, add water for injection to make up to 1000ml.

[0033] The preparation method of the bacteriostatic-free recombinant human basic fibroblast growth factor gel provided in this example is the same as that in Example 1.

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Abstract

The invention provides a recombinant human basic fibroblast growth factor gel without a bacteriostatic agent. The recombinant human basic fibroblast growth factor gel comprises the following components: 1*10<6> to 9*10<6> IU of recombinant human basic fibroblast growth factors, 0.01 to 5.0 g of albumen stabilizers, 0.1 to 20.0 g of thickeners, 0.1 to 10.0 g of pH regulators, 0.1 to 10.0 g of buffering agents and 0.1 to 50.0 g of humectants, and water for injection is added to a constant volume of 1000 ml. The invention further provides a preparation method of the recombinant human basic fibroblast growth factor gel without the bacteriostatic agent. The recombinant human basic fibroblast growth factor gel without the bacteriostatic agent is disposable, so as to prevent eyes from being stimulated by the bacteriostatic agent and avoid microbial contamination which possibly occurs in the processes of use and storage.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a recombinant human basic fibroblast growth factor gel containing no bacteriostatic agent and a preparation method thereof. Background technique [0002] Basic fibroblast growth factor (bFGF) is an endogenous active factor closely related to the healing process of tissue wounds, which can significantly promote tissue wound healing, nerve injury repair and angiogenesis. bFGF is a single-chain polypeptide composed of 146 amino acids with a molecular weight of 17KD. Clinical application shows that rh-bFGF has a significant healing effect on human body burns, wounds, surgical injuries, etc., and has no local and systemic toxic side effects. bFGF can not only accelerate wound healing, but also reduce scar formation, and has demonstrated extraordinary and unique effects in promoting the regeneration and repair of tissue damage such as burns, wounds and bedsores. [0003] The recom...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/06A61P27/02A61P17/02
Inventor 曲伟许岩邓春平方海洲王新志
Owner ZHUHAI ESSEX BIO PHARMA
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