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Spinal cord micro-catheter stent fast to form and manufacturing method thereof

A technology for microcatheter and spinal cord, applied in the field of rapid prototyping spinal cord microcatheter stent and its preparation, can solve the problems of spatial structure gap, limited nerve function repair effect, etc., achieves high accuracy, promotes orderly directional growth, and high additional effect of value

Inactive Publication Date: 2015-11-11
THE CHINESE PEOPLES ARMED POLICE LOGISTICS INST AFFILIATED HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the neural conduits prepared by the current technology not only have a limited repair effect on nerve function, but also have a large gap between the spatial structure and the spinal cord in vivo.

Method used

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  • Spinal cord micro-catheter stent fast to form and manufacturing method thereof
  • Spinal cord micro-catheter stent fast to form and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 rapidly prototyping spinal cord microcatheter support

[0034] Such as figure 1 , 2 As shown, it includes an elliptical cylindrical microcatheter stent body, and the microcatheter stent body is provided with hollow areas for growing corticospinal tracts, thin tracts, wedge tracts and spinothalamic tracts; the hollow areas include the first support area 1, the second Stent region 2 and the third stent region 3; the center of the upper half of the microcatheter stent body is provided with the first stent region 1 for growing thin bundles and wedge bundles; , The second bracket area 2 of the spinothalamic tract; the third bracket area 3 is arranged below the first bracket area 1; the outer diameter of the spinal cord microcatheter bracket is 2.5-3.5 mm, and the wall thickness is 0.1-1.0 mm; the third bracket area 3 With a diameter of 200-400 μm, the third scaffold area is used for precision control.

[0035] The spinal cord microcatheter scaffold of the pre...

Embodiment 2

[0039] The preparation of embodiment two spinal cord microcatheter support

[0040] (1) Prepare a fresh spinal cord sample at the thoracic 10 level of the rat, and measure its main parameter data, such as diameter, transverse diameter, hardness, elastic modulus, and strength;

[0041] (2) According to the anatomical structure and measurement data of the rat spinal cord, comparative analysis was carried out to understand the diameter and course of the spinal corticospinal tract, spinothalamic tract, thin tract and wedge tract, design and optimize the 3D model of the spinal cord microcatheter scaffold, and conduct finite element analysis Analysis; import the 3D model of the spinal cord microcatheter into the 3D bioprinter computer for format conversion, data simulation and parameter optimization;

[0042] (3) Take silk protein as raw material, take silk, put silk raw material into 80-120 ℃ Na 2 CO 3 solution, boiled at high temperature for 30-60min, washed repeatedly with dist...

Embodiment 3

[0046] The preparation of embodiment three spinal cord microcatheter support

[0047] (1) According to the comparative analysis of the anatomical structure and measurement data of the spinal cord nerves in rats, understand the diameter and course of the spinal corticospinal tract, spinothalamic tract, thin tract and wedge tract, design and optimize the 3D model of the spinal cord microcatheter scaffold, and conduct finite element analysis Analysis; import the 3D model of the spinal cord microcatheter into the 3D bioprinter computer for format conversion, data simulation and parameter optimization. The diameter is 2.5-2.8mm and the transverse diameter is 2.2-2.5mm;

[0048] (2) Using silk protein and hydroxyapatite as raw materials, take silk, and put the silk raw material into 80-120°C Na 2 CO 3 solution, boiled at high temperature for 30-60min, washed repeatedly with distilled water; repeated boiling and washing 2-3 times, vacuum drying to complete degumming; 2 , ethanol, w...

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Abstract

The invention provides a spinal cord micro-catheter stent fast to form. The spinal cord micro-catheter stent comprises a micro-catheter stent body in an elliptic cylinder shape. A hollow area used for allowing corticospinal tracts, fasciculus gracilis, fasciculus cuneatus and spinothalamic tracts to grow is arranged in the micro-catheter stent body. The outer diameter of the spinal cord micro-catheter stent body is 2.5 mm-3.5 mm, and the wall thickness of the micro-catheter stent body is 0.1 mm-1.0 mm. The size and the microscopic structure of a model are designed according to the electrophysiology structure and the exquisite position of natural nerves of the spinal cord, the low-temperature fast forming printing technology is adopted for accurately printing the fine structure of a patient, and the stent can be used for treatment and research on spinal cord injuries.

Description

technical field [0001] The invention relates to a rapidly prototyping spinal cord microcatheter support and a preparation method thereof. Background technique [0002] For a long time, limb dysfunction caused by spinal cord injury has always been a difficult problem in the medical field. At present, its treatment strategy is to promote and guide the growth of proximal spinal cord axons across the injured segment, connecting them to the distal end, and at the same time inhibit the adverse pathophysiological responses after spinal cord injury, such as distal Wallerian degeneration. In 1944, Weiss et al proposed the concept of sutureless catheterization to repair nerve damage. According to this concept, subsequent scholars used tissue-engineered, biologically active nerve substitutes, namely nerve conduits, to replace autologous nerve grafts with limited sources to repair peripheral nerve defects. However, due to the special structure and function of the spinal cord itself, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/44A61L27/58
Inventor 涂悦李瑞欣陈旭义张赛汤锋武马军刘红斌刚琳
Owner THE CHINESE PEOPLES ARMED POLICE LOGISTICS INST AFFILIATED HOSPITAL
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