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A method for constructing a diagnostic model of esophageal squamous cell carcinoma, the obtained diagnostic model, and a method for using the model

A construction method and a technology for diagnosing models, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of inability to realize early diagnosis of esophageal cancer, high sensitivity of advanced esophageal cancer, and complicated diagnostic operation, so as to achieve simple diagnosis process and reduce pain , the effect of reducing mortality

Active Publication Date: 2017-03-08
SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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Problems solved by technology

[0007] Aiming at the shortcomings of esophageal squamous cell carcinoma (referred to as esophageal cancer) in the prior art, which are complex, expensive, and traumatic, and the current markers are only highly sensitive to advanced esophageal cancer, and cannot achieve early diagnosis of esophageal cancer, this paper The invention provides a diagnostic marker suitable for the early diagnosis of esophageal squamous cell carcinoma. The diagnostic marker has good sensitivity and specificity for esophageal carcinoma in situ, early esophageal cancer, and advanced esophageal cancer. It can not only be used for The diagnosis of advanced esophageal cancer can also be better used for the early diagnosis of esophageal squamous cell carcinoma, which is of great significance for improving the prognosis and reducing mortality of esophageal squamous cell carcinoma

Method used

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  • A method for constructing a diagnostic model of esophageal squamous cell carcinoma, the obtained diagnostic model, and a method for using the model
  • A method for constructing a diagnostic model of esophageal squamous cell carcinoma, the obtained diagnostic model, and a method for using the model
  • A method for constructing a diagnostic model of esophageal squamous cell carcinoma, the obtained diagnostic model, and a method for using the model

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Embodiment Construction

[0072] Below, the present invention is further explained through the following specific embodiments, and the advantages of the present invention are further proved.

[0073] The screening of the diagnostic markers of the present invention, the construction method of the diagnostic model and the effect verification are as follows:

[0074] 1. Research object

[0075] Relying on the esophageal cancer screening platform of "National Demonstration Base for Early Diagnosis and Treatment of Esophageal Cancer (Feicheng City, Shandong Province)", this study targeted iodine-stained biopsy subjects aged 40-69 under gastroscope in Feicheng City, Shandong Province (confirmed as the gold standard) Collect esophageal carcinoma in situ (39 cases at stage 0), early esophageal cancer (17 cases at stage I, 11 cases at stage II) and advanced esophageal cancer (30 cases at stage III); The test subjects were 105 healthy subjects without upper gastrointestinal lesions as healthy samples.

[0076]...

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Abstract

The invention discloses a building method of an esophageal squamous cell cancer diagnosis model. The method comprises the following steps that blood serum samples of esophageal cancer and healthy people groups are collected; an LC-MS serum metabolomics technology is adopted for an analysis to obtain an original metabolic fingerprint atlas; the original metabolic fingerprint atlas is subjected to atlas preprocessing and metabolite peak marking to obtain a two-dimensional matrix; information of a diagnosis marker suitable for an esophageal squamous cell cancer early-stage diagnosis is screened out from the two-dimensional matrix to obtain a diagnosis marker two-dimensional matrix; according to the diagnosis marker two-dimensional matrix, a random forest software packet in R language is used for building a random forest model to obtain the esophageal squamous cell cancer diagnosis model. The invention also discloses the diagnosis model and a use method of the diagnosis model. The model building method provided by the invention is simple; the obtained diagnosis model has the advantages of good effect, high sensitivity and good specificity, is suitable for late-stage and early-stage esophagus cancer diagnoses, and has good clinic use and popularization value.

Description

technical field [0001] The present invention relates to the diagnosis of esophageal squamous cell carcinoma, in particular to a diagnostic marker for esophageal squamous cell carcinoma, a screening method for the diagnostic marker, a diagnostic model based on the diagnostic marker, and a method for constructing the diagnostic model. The diagnostic marker and diagnostic model have good diagnostic effects on esophageal carcinoma in situ, early and advanced esophageal cancer, are particularly suitable for early diagnosis of esophageal cancer, and belong to the technical field of diagnosis of esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is a malignant lesion formed by abnormal proliferation of esophageal squamous or glandular epithelium. According to the latest data from the World Health Organization, about 400,000 people die from esophageal cancer every year in the world. my country is the country with the highest incidence and mortality r...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574
CPCG01N33/57446
Inventor 王家林薛付忠张涛赵德利朱正江
Owner SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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