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Hypoglycemic composition and application thereof

A composition and hypoglycemic technology, applied in the directions of drug combination, heavy metal compound active ingredient, application, etc., can solve the problems of increased cost, increased sensitivity of pancreatic islet receptors, large dose, etc., and achieve the effect of improving the effect

Active Publication Date: 2015-11-18
张丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese Patent Authorization Announcement No. CN102860451B discloses the joint administration of oligochitosan and L-arabinose, while using oligochitosan to promote the secretion of human insulin, increase the sensitivity of islet receptors, and enhance the utilization of blood sugar, taking L-arabinose to inhibit the human body The absorption of sucrose reduces the production and absorption of glucose, thus through two-way regulation, but its hypoglycemic effect is still unsatisfactory
It is obviously impossible to use 210±3.7g mice in the hypoglycemic experiment in the patent description, and the weight of the mice cannot reach 210g, which only shows that the hypoglycemic effect is not obvious, and the recommended dosage for adults is 10.2g / day , the dose is very large, it is not suitable for marketing, and other raw materials such as taurine and wolfberry extract are added, which increases the cost
[0007] Therefore, the therapeutic effect of the above ingredients is still not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Raw materials: L-arabinose 3340g, chitooligosaccharides 660g, chromium-rich yeast 160g (containing 0.32g trivalent chromium), accessories: starch 340g

[0043] The L-arabinose is crushed and passed through an 80-mesh sieve; the chitosan, chromium-rich yeast, and starch are respectively passed through an 80-mesh sieve for use. The chromium-rich yeast and oligochitosan are mixed uniformly, and then mixed with L-arabinose and starch in a mixer for 30 minutes to obtain a mixed powder for use. Add 80% ethanol to the above mixed powder and stir to prepare soft material, granulate with 20 mesh, dry at 50-60 DEG C, and granulate with 20 mesh to obtain granules. Fill the particles with 0.45 g / capsule, and polish and screen the obtained capsules, and reject the unqualified products to obtain qualified capsules.

Embodiment 2

[0045] Raw materials: 5010g of L-arabinose, 990g of chitooligosaccharides, 240g of chromium-rich yeast (containing 0.48g of trivalent chromium), auxiliary materials: 3760g of mannitol.

[0046] The L-arabinose is crushed and passed through an 80-mesh sieve; the chitosan oligosaccharide, chromium-rich yeast, and mannitol are respectively passed through an 80-mesh sieve for use. The chromium-rich yeast and the chitosan oligosaccharide are mixed uniformly, and then mixed with L-arabinose and mannitol in a mixer for 30 minutes to obtain a mixed powder for use. Divide the mixed powder into 2g / bag. Immediately.

Embodiment 3

[0048] Raw materials: 2400g of L-arabinose, 480g of chitooligosaccharides, 120g of chromium-rich yeast (containing 0.24g of trivalent chromium), 1752g of mannitol, auxiliary materials: 48g of magnesium stearate.

[0049] The L-arabinose is crushed and passed through an 80-mesh sieve; the chitosan, chromium-rich yeast, mannitol, and magnesium stearate are respectively passed through an 80-mesh sieve. The chromium-rich yeast and the chitosan oligosaccharide are mixed uniformly, and then mixed with L-arabinose and mannitol in a mixer for 30 minutes to obtain a mixed powder. Add 30% ethanol to the above mixed powder and stir to make a soft material, 20 mesh Granules are dried at 40-50°C to a moisture content of 3.0-5.0%, 24 meshes are granulated to obtain dry granules. Put the dry granules and magnesium stearate into a mixer and mix for 10 minutes, mix evenly, to obtain the total mixed granules. The total mixed granules are pressed into tablets, 1g / tablet, to obtain chewable tablets...

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Abstract

The present invention provides a hypoglycemic composition and application thereof. The composition provided by the invention comprises L-arabinose, chitosan oligosaccharide, trivalent chromium and accessories. The composition of the present invention has significantly improved effect of treating diabetes better than any two of the individual usage of L-arabinose, chitosan oligosaccharide and trivalent chromium. The composition provided by the present invention is applicable to the preparation of food, medicines and health care products, and can be used for the treatment or prevention of hyperglycemia.

Description

Technical field [0001] The invention relates to a blood glucose composition and its use. Specifically, it relates to a composition comprising L-arabinose, chitooligosaccharide and trivalent chromium and its use in preventing and treating hyperglycemia. technical background [0002] Diabetes is a common chronic metabolic disease. The clinical feature is elevated blood sugar. In typical cases, symptoms such as polydipsia, polyphagia, polyuria, and weight loss can be seen. With the improvement of people's living standards and the progress of aging society, the incidence of diabetes is getting higher and higher. [0003] The main methods of treating diabetes are: ①Promote the synthesis and secretion of insulin. The mechanism of action of this kind of drugs is to directly stimulate the pancreatic β-cells to secrete insulin and have a hypoglycemic effect; ②Promote the effect of peripheral tissues (such as muscles) on glucose and inhibit glycogen Metagenesis and the uptake of glucose by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/064A61K33/00A61K31/722A61P3/10A23L1/29A23G3/36A61K31/7004A61K31/28A61K31/555A23L33/00
Inventor 张丽
Owner 张丽
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