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A kind of traditional Chinese medicine composition and its preparation method and application

A technology for a composition and a traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its preparation, can solve the problems of increasing production cost and process complexity, risks caused by consumers' health and safety, etc., and achieves the effect of reducing the content

Active Publication Date: 2019-08-06
CHENGDU HUASUN GRP INC LTD +1
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0006] Although there are many kinds of traditional Chinese medicine liver protection health care products on the market, there are too many kinds of traditional Chinese medicine used in these products. In other words, too many components of traditional Chinese medicine will also increase the production cost and process complexity. Therefore, how to achieve auxiliary protection against alcoholic liver injury with fewer components of traditional Chinese medicine is a promising research direction

Method used

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  • A kind of traditional Chinese medicine composition and its preparation method and application
  • A kind of traditional Chinese medicine composition and its preparation method and application
  • A kind of traditional Chinese medicine composition and its preparation method and application

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Effect test

Embodiment 1

[0039] Embodiment 1: the preparation of Chinese medicine composition of the present invention

[0040] 1. Preparation of notoginsengdiol saponins

[0041] Clean the notoginseng (head) and control the temperature at 55-60°C, dry it until there is no moisture to the touch, and then pulverize it into powder, soak it in 60% ethanol for ≥24 hours, then put it into a tube and start percolation, and control the flow rate at 5-8ml / Min kg of medicinal materials, collect the notoginseng percolation liquid, concentrate the notoginseng percolation liquid until the specific gravity is 1.08-1.12, and collect the ointment, the concentration temperature is ≤70°C, then add water and stir to form a notoginseng aqueous solution, and use macroporous adsorption resin chromatography;

[0042] The flow rate of the Panax notoginseng aqueous solution on the column is ≤600L / h. After loading the column, first wash with water at 800L / h for half an hour, then with water at 1200L / h for half an hour, and f...

Embodiment 2

[0053] Embodiment 2: the preparation of liver protection tablet

[0054] Mix 25 parts of kudzu root extract, 10 parts of salvia miltiorrhiza extract, 150 parts of notoginseng glycol saponins, 60 parts of microcrystalline cellulose, 120 parts of pregelatinized starch, and 120 parts of dextrin with a three-dimensional mixer for 10 minutes; then use 16 parts 14% starch slurry was prepared by starch boiling method; the starch slurry was mixed with the above mixture, and wet granulation was carried out with a swinging vibrating sieve; the granules were dried in a hot air circulation oven at 60°C for 3 hours, and then taken out; The water content of the granules is checked by an instrument (less than 10%); 2.5 parts by weight of magnesium stearate are added for total mixing and then compressed into tablets; and then film-coated to obtain the final product.

Embodiment 3

[0055] Embodiment 3: Security testing

[0056] 1. Experimental animals: 20 SPF grade SD rats, half male and half female, weighing 180g-220g; 20 SPF Kunming mice, half male and half female, weighing 18g-22g, all provided by Chengdu Dashuo Biotechnology Co., Ltd. Certificate number: SCXK (Sichuan) 2008-24. Quarantine for one week before the test. During the whole test, the animals were free to eat and drink, the room temperature was 21°C-24°C, and the relative humidity was 50%-65%.

[0057] 2. Test method

[0058] Acute oral toxicity test in rats: taking the traditional Chinese medicine composition 1 of the present invention as the detection object, the maximum tolerated dose method was used to conduct the test, and a dose group of 10 g / kg was set up in the test. There were 10 male and female SD rats in each group. Sample preparation: Accurately weigh 50g of the sample, dissolve it in distilled water and make up to 200ml, orally orally gavage the animal twice with an interval...

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Abstract

The invention relates to the technical field of traditional Chinese medicine health products and discloses a traditional Chinese medicine composition as well as a preparation method and application thereof. The traditional Chinese medicine composition is composed of pseudo-ginseng diol saponin, a salvia miltiorrhiza extractive and a kudzuvine root extractive; the salvia miltiorrhiza extractive and the kudzuvine root extractive are obtained through reflux extraction by ethyl alcohol. According to the invention, pseudo-ginseng, salvia miltiorrhiza and kudzuvine root are selected as Chinese herbal compounds, the novel traditional Chinese medicine composition is obtained by adopting a modern extraction technology, the auxiliary protection function of reducing alcoholic liver injury can be realized through fewer components, particularly, the phenomenon that the contents of triglyceride and very low density lipoprotein increase caused by alcoholic liver injury is reduced obviously and the traditional Chinese medicine composition can be applied to preparation of drugs and health products for protecting the liver.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine health products, in particular to a traditional Chinese medicine composition and its preparation method and application. Background technique [0002] At present, my country is one of the countries with a high incidence of liver disease. Finding and researching effective drugs for treating liver disease has always been the wish of the majority of scientific researchers, and more and more attention has been paid to it. Therefore, health care products with liver protection are also more and more popular more and more people's attention. [0003] Traditional Chinese medicine health care products are favored by consumers because of their small side effects. There are many traditional Chinese medicine health products on the market that help reduce chemical liver damage (alcoholic liver damage), such as the various commercially available products recorded in Table 1: [0004] Table 1 [000...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A23L33/105A61P1/16A23L33/00
Inventor 杨华蓉王莉曹科张天洋高星卢瀚思
Owner CHENGDU HUASUN GRP INC LTD
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