Application of external timolol preparations in treating infantile hemangioma and preparation method thereof

A technology for infantile hemangioma and external preparation, applied in the field of pharmacy, can solve problems such as adverse effects on organ tissue and function, and achieve the effects of fast onset, high safety and definite curative effect

Pending Publication Date: 2015-12-02
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most hemangiomas are self-limited and regress gradually with age; however, the development of some hemangio

Method used

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  • Application of external timolol preparations in treating infantile hemangioma and preparation method thereof
  • Application of external timolol preparations in treating infantile hemangioma and preparation method thereof
  • Application of external timolol preparations in treating infantile hemangioma and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0022] The preparation method of described gel:

[0023] The preparation process is basically the same: raw and auxiliary materials are weighed according to the prescription. Add an appropriate amount of water to the gel matrix and stir to swell, dissolve the raw materials and moisturizing agent, add it to the swollen matrix, add the ethanol solution dissolved in preservatives and transdermal penetration enhancers, and add enough water to stir evenly.

Embodiment 1

[0025] Prescription (according to 100g): 0.5g timolol maleate, 2g sodium carboxymethylcellulose, 1g farnesol, 12g propylene glycol, 1g ethylparaben, appropriate amount of ethanol, and the rest is water.

Embodiment 2

[0027] Prescription (according to 100g): 1g timolol maleate, 3g carbomer, 2g peppermint oil, 8g glycerin, 0.5g sorbic acid, appropriate amount of ethanol, and the rest is water.

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Abstract

The invention discloses application of external timolol preparations in treating infantile hemangioma and a preparation method thereof, belongs to the field of pharmacy and aims to providing various timolol preparations supportive of external use and used for treating infantile hemangioma. Various external preparations like gels, plastics, paste and pigmentum can be prepared by adding proper auxiliary materials like gel substrate, percutaneous penetration enhancer, preservative, humectant, emulsifier, film forming material and oily substrate. The external timolol preparations have the advantages of high safety, accurate curative effect, high tolerance and quickness in taking effect.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to an external preparation of timolol and a preparation method thereof. Background technique [0002] Hemangioma is one of the most common benign lesions in infants, with an incidence rate of 8.7% to 12.7%, and its prevalence rate can be as high as 22% in premature or low birth weight infants, of which about 60% of hemangiomas occur in head and neck. Most hemangiomas are self-limited and will gradually regress with age; however, the development of some hemangiomas may have adverse effects on life, organ tissue and function, and appropriate treatment is required at this time. Current treatments for hemangiomas include drugs, surgery, lasers, and radiation. [0003] Since the first report in 2008 that the use of propranolol in the treatment of infantile hemangioma achieved better curative effect, researchers at home and abroad have paid more and more attention to the efficacy and safety of β-b...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/70A61K31/5377A61P35/00
Inventor 李化淋
Owner 天津市聚星康华医药科技有限公司
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