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Pharmaceutical composition for resisting renal fibrosis and application of pharmaceutical composition

A kind of technology of renal fibrosis and composition, applied in the field of anti-renal fibrosis pharmaceutical composition, can solve the problems such as unsatisfactory curative effect and the like

Inactive Publication Date: 2015-12-02
江志鑫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine uses hormones, interferon, ACEI and other anti-fibrosis, but the curative effect is not satisfactory. At present, there is no specific drug for the treatment of renal fibrosis

Method used

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  • Pharmaceutical composition for resisting renal fibrosis and application of pharmaceutical composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of Chinese medicine extract

[0013] Herbal medicine prescription: corn silk 5.0kg, golden silk grass 2.5kg, centella asiatica 2.5kg, nepeta 1.8kg, liuyuexue 1.8kg, cork 1.1kg, bamboo ruthenium 0.7kg, bergamot 0.6kg, alisma 0.9kg, purple Grass 0.9kg.

[0014] Preparation process: Weigh the above-mentioned Chinese medicinal materials in the prescribed amount, combine them, crush them, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct for 2 times, add the medicinal materials for the first time 12 times the amount of purified water, decoct for 2 hours, take the decoction, filter, add up the purified water of 10 times the amount of medicinal materials for the second time, decoct for 1.5 hours, take the two decoctions and combine, filter, and concentrate to every ml Containing 1.0g of crude drug, stir evenly, refrigerate at 5°C for ...

Embodiment 2

[0015] Embodiment 2: the preparation of Chinese medicine oral liquid

[0016] Herbal medicine prescription: corn silk 5.0kg, golden silk grass 2.5kg, centella asiatica 2.5kg, nepeta 1.8kg, liuyuexue 1.8kg, cork 1.1kg, bamboo ruthenium 0.7kg, bergamot 0.6kg, alisma 0.9kg, purple Grass 0.9kg.

[0017] Preparation process: Weigh the above-mentioned Chinese medicinal materials in the prescribed amount, combine them, crush them, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, add the medicinal materials for the first time 12 times the amount of purified water, decoct for 2 hours, take the decoction, filter, add up the purified water of 10 times the amount of medicinal materials for the second time, decoct for 1.5 hours, take the two decoctions and combine, filter, and concentrate to every ml Containing 2.5g of crude drug, stir evenly, refrigerate at 5°C for 24...

Embodiment 3

[0018] Embodiment 3: the preparation of Chinese medicine oral liquid

[0019] Herbal medicine prescription: corn silk 5.3kg, golden silk grass 2.6kg, centella asiatica 2.6kg, nepeta 2.2kg, liuyuexue 2.2kg, cork 1.4kg, bamboo ruthenium 0.9kg, bergamot 0.9kg, alisma 0.9kg, purple Grass 0.9kg.

[0020] Preparation process: Weigh the above-mentioned Chinese medicinal materials in the prescribed amount, combine them, crush them, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, add the medicinal materials for the first time 12 times the amount of purified water, decoct for 2 hours, take the decoction, filter, add 10 times the amount of purified water of the medicinal materials for the second time, decoct for 2 hours, take the two decoctions and combine, filter, and concentrate to contain 2.8g crude drug amount, stir evenly, refrigerate at 5°C for 24 hours, filte...

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Abstract

The invention discloses a pharmaceutical composition for resisting renal fibrosis and application of the pharmaceutical composition. The medicine composition is prepared by performing decocting extraction on the following traditional Chinese medicinal materials in parts by mass: 40-60 parts of corn stigma, 21-30 parts of rough melic herb, 21-30 parts of centella asiatica, 15-22 parts of herba schizonepetae, 15-22 parts of serissa serissoide, 8-14 parts of cortex phellodendri, 5-9 parts of bamboo shaving, 3-9 parts of fingered citron, 6-12 parts of rhizoma alismatis and 6-12 parts of lithospermum. The medicine composition can be used for remarkably improving nephridial tissue FN, III type collagen and alpha-SMA expression in an aristolochic acid caused renal fibrosis model and improving the situations of kidney tissue basilar membrane swelling and dense deposit disease, has a certain effect for resisting renal fibrosis, and can be used for preventing and treating renal fibrosis diseases.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for resisting renal fibrosis and its application. Background technique [0002] Renal fibrosis is the common path and the main pathological basis for various kidney diseases to progress to chronic renal failure. It is characterized by abnormal deposition of extracellular matrix (ECM). Its gradual development will eventually lead to the loss of kidney function, which is life-threatening. Western medicine uses hormones, interferon, ACEI and other anti-fibrosis, but the curative effect is not satisfactory, and there is no specific drug for the treatment of renal fibrosis at present. Contents of the invention [0003] In view of the existence of western medicine in the treatment of renal fibrosis, the purpose of the present invention is to conduct in-depth research and optimization of folk traditional Chinese medicine p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P13/12
Inventor 不公告发明人
Owner 江志鑫
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