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Mannitol Injection

A technology of injection and mannitol, which is applied in the field of pharmaceutical preparations, can solve problems such as unsatisfactory solubilization effect, large blood vessel irritation, and high drug concentration, so as to eliminate cerebral edema, less blood vessel stimulation, and reduce intracranial pressure Effect

Active Publication Date: 2018-06-29
GUANGXI YUYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the crystallization probability of mannitol glucose injection is extremely low, it is not suitable for diabetic patients, and its dehydration effect is weaker than that of ordinary mannitol injection; compound mannitol may also have the same disadvantages as other injection drugs: there may be Higher incidence of allergies, and it is a hypertonic solution with high drug concentration and greater irritation to blood vessels. Most patients have obvious pain during intravenous infusion
In addition, improving the formula of mannitol injection and improving the crystallization of mannitol can also be achieved by adding co-solvents and other excipients, but generally the excipients with better solubilization are less safe, while the excipients with better safety have a solubilizing effect not ideal
From this point of view, mannitol injections with good curative effect and high safety without crystallization at low temperature are still very limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Mannitol injection is made from the following raw materials in percentage by weight:

[0019]

[0020] The preparation method of mannitol injection: take mannitol, olive oil and Tween 80 and dissolve in an appropriate amount of water for injection; add 0.2% W / V activated carbon for needles, heat to boil, filter; add the remaining amount of water for injection, and mix well After filtering, filling and sealing, autoclaving at 121°C for 15 minutes, the product is ready.

Embodiment 2

[0022] Mannitol injection is made from the following raw materials in percentage by weight:

[0023]

[0024] The preparation method of mannitol injection: take mannitol, olive oil and Tween 80 and dissolve in an appropriate amount of water for injection; add 0.3% W / V activated carbon for needles, heat to boil, filter; add the remaining amount of water for injection, and mix well After filtering, filling and sealing, autoclaving at 121°C for 15 minutes, the product is ready.

Embodiment 3

[0026] Mannitol injection is made from the following raw materials in percentage by weight:

[0027]

[0028] The preparation method of mannitol injection: take mannitol, olive oil and Tween 80 and dissolve in an appropriate amount of water for injection; add 0.1% W / V activated carbon for needles, heat to boil, filter; add the remaining amount of water for injection, and mix well After filtering, filling and sealing, autoclaving at 121°C for 15 minutes, the product is ready.

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PUM

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Abstract

The invention relates to the technical field of pharmaceutic preparations, in particular to a mannitol injection. The mannitol injection is prepared from, by weight, 14%-20% of mannitol, 3%-9% of olive oil, 1%-7% of tween 80 and the balance of water for injection. According to the mannitol injection, the curative effect is good, crystals do not occur at low temperature, the use safety is high, and the phenomena of allergies and hemolysis do not occur.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a mannitol injection. Background technique [0002] Mannitol is a kind of hexanehexol, which is an isomer of sorbitol. It is a good diuretic and dehydrating drug. It is used to treat cerebral edema and increased intracranial pressure caused by various reasons. It is also used in other eye-reducing diseases. When internal pressure medicine is ineffective or before intraocular surgery. At 20°C, the solubility of mannitol in water is 1:5.5 (18%), and 20% mannitol injection is a supersaturated solution. When the room temperature is lower than 15°C, mannitol particles are easily produced, and even crystals are precipitated. When the temperature continues to drop, the crystals increase in size and become large columnar and flocculent crystals. If the packaging is a plastic soft bag, it will cause damage and increase the risk of medication. The particles in the man...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/047A61K47/44A61K47/26A61P7/10
Inventor 庞春林罗世东王亚军陈兴华廖柳艳王敏
Owner GUANGXI YUYUAN PHARMA
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