A kind of pharmaceutical composition containing pramipexole hydrochloride and preparation method thereof

A technology of pramipexole hydrochloride and composition, which is applied in the field of pharmaceutical preparations, and can solve the problems of poor compatibility of pramipexole hydrochloride and failure to meet the requirements of preparations, etc.
CN105147627BActive Publication Date: 2019-04-12TIANJIN CHASE SUN PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN CHASE SUN PHARM CO LTD
Publication Date
2019-04-12

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Abstract

The invention relates to medicine composition containing pramipexole dihydrochloride and a preparation method thereof. The composition is orally disintegrating tablets and comprises components in percentage by weight in the specification. The preparation process of the pramipexole dihydrochloride orally disintegrating tablets is simple, and the pramipexole dihydrochloride orally disintegrating tablets taste good, have better compliance for medicine taking by comparison with products on the current market and are especially suitable for the special population such as the old, people who have difficulty in swallowing and the like.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical composition containing pramipexole hydrochloride and a preparation method thereof. Background technique

[0002] Pramipexole hydrochloride is a dopamine receptor agonist.

[0003] The chemical formula is as follows:

[0004]

[0005] (s)-2-Amino-4,5,6,7-tetrahydro-6-propylamine-benzothiazole, molecular formula C 10 h 19 C l2 N 3 S.H 2 O, the molecular weight is 302.27.

[0006] Pramipexole hydrochloride monohydrate dihydrochloride is commonly used in preparations.

[0007] Pramipexole hydrochloride is pharmacologically a full agonist and has receptor selectivity for the dopamine D2 family of dopamine receptors. It is used to treat conditions such as Parkinson's disease and restless legs syndrome. At present, the marketed dosage forms include ordinary tablets and sustained-release tablets. mg, 0.75mg, 1.5mg, 2.25mg, 3mg, 3.75mg and 4.5mg and...

Claims

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