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Artificial saliva and preparation method thereof

A technology of artificial saliva and solution, applied in the field of artificial saliva, can solve the problems of destruction, lung infection endangering life, entering the lungs, etc., and achieve the effect of promoting absorption, good sterilization effect, and inhibiting bacterial growth.

Active Publication Date: 2015-12-16
JIANGSU HAIERZI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, a large number of pathogenic bacteria will be produced in the oral cavity of some clinically critically ill patients. Due to the decline in immunity of critically ill patients, the oral flora will be destroyed, resulting in a large number of oral bacteria and other pathogenic microorganisms. The respiratory tract enters the lungs, causing lung infections that are life-threatening. At present, in clinical medicine, antibiotics are mostly used for the above-mentioned situations. Extensive use of antibiotics will cause damage to the body's own immune system to a certain extent.

Method used

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  • Artificial saliva and preparation method thereof
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  • Artificial saliva and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 (best)

[0048]

[0049] The artificial saliva preparation method is as follows:

[0050] Dissolve carboxymethyl chitosan directly in water for injection to obtain solution ①, set aside;

[0051] Sodium chloride, potassium chloride, and calcium chloride are dissolved in water for injection to obtain a solution ② for subsequent use;

[0052] Dissolve mannitol in water for injection to prepare solution ③ for subsequent use;

[0053] After mixing the above three solutions, add 1.0% grapefruit seed extract, then add buffer solution sodium dihydrogen phosphate to adjust the pH of the system solution to about 5.5; after emulsification forms a uniform sol-like liquid system, heat and boil for 30 minutes, then add Sufficient water for injection;

[0054] The above-prepared solution was subjected to suction filtration, fine filtration, aseptic filling, and sterilized by high-pressure steam at 121° C. for 30 minutes to obtain a finished product. The measured pH va...

Embodiment 2

[0056]

[0057] The artificial saliva preparation method is as follows:

[0058] Dissolve chitosan in dilute acetic acid solution (add 1 ml of glacial acetic acid per 100 ml of water for injection) to obtain solution ①, for later use;

[0059] Dissolve sodium chloride, potassium chloride and calcium chloride in water for injection to obtain solution ②, for subsequent use;

[0060] Glycine is dissolved in water for injection to obtain solution 3. for subsequent use;

[0061] After mixing the above three solutions, add 0.5% grapefruit seed extract, and then add buffer sodium dihydrogen phosphate to adjust the pH of the system solution to about 5.5; after forming a homogeneous sol-like liquid system by emulsification, heat and boil for 30 minutes, then add Water for injection to a sufficient amount;

[0062] The solution prepared above was subjected to suction filtration, fine filtration, aseptic filling, and then autoclaved and sterilized at 121° C. for 30 minutes to obtain a...

example 3

[0064]

[0065]

[0066] The artificial saliva preparation method is as follows:

[0067] The water-soluble chitosan quaternary ammonium salt is directly dissolved in water for injection to obtain solution ①, which is for later use;

[0068] Dissolve sodium chloride in water for injection to obtain solution ②, for subsequent use;

[0069] Glycine is dissolved in water for injection to obtain solution 3. for subsequent use;

[0070] After mixing the above three solutions, add 1.5% grapefruit seed extract, and then add buffer sodium dihydrogen phosphate to adjust the pH of the system solution to about 5.0; after forming a homogeneous sol-like liquid system by emulsification, heat and boil for 30 minutes, and then add Water for injection to a sufficient amount;

[0071] The above-prepared solution was subjected to suction filtration, fine filtration, aseptic filling, and sterilized by autoclaving at 121° C. for 30 minutes to obtain a finished product, and the measured pH ...

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Abstract

The invention discloses artificial saliva and a preparation method thereof. The artificial saliva is prepared by main components of chitosan and a grapefruit seed extractive and taking water for injection or purified water as a carrier. The artificial saliva is applicable to the perioperative period and tumor, relieving mouth drying of a radiation and chemotherapy patient and curing and preventing complication caused by mouth drying. Refractory dental ulcer caused by unbalance of oral bacteria due to hypoimmunity is cured. The artificial saliva is applied to infection of pathogenic microorganisms of bacteria and the like caused by unbalance of oral bacteria due to hypoimmunity of a sever clinic patient and a long-time bedridden patient and is used for preventing pulmonary infection so that the use amount of antibiotics is reduced. The artificial saliva has no toxicity to a human body, no irritation to mucosa and no sensitization, excellent biodegradability and good anti-bacteria, anti-inflammation, pain relieving, hemostasis and ulcer surface curing promoting effects.

Description

technical field [0001] The invention relates to an artificial saliva, which is mainly used in the clinical perioperative period and in patients with tumors, radiotherapy and chemotherapy for dry mouth relief, oral cleaning care, treatment of stubborn oral ulcers caused by imbalance of oral flora due to low immunity, prevention of dental caries, and treatment of gums diseases such as inflammation. Background technique [0002] At present, in the clinical perioperative period, such as pancreatic surgery patients, they need to fast and drink water. Because they cannot drink water directly, the patients have symptoms of dry mouth and even chapped and ulcers; for cancer patients and patients with radiotherapy and chemotherapy, the salivary gland damage caused by chemotherapy drugs and radiation cannot be cured. Or the reduction of saliva secretion causes dry mouth in patients, which tortures the patient's psychology and physiology, and even endangers the normal life of patients. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/02A61K31/722A61K33/14A61K33/06
Inventor 胡军胡梦
Owner JIANGSU HAIERZI BIOTECH CO LTD
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