A Light Irradiation Device for Establishing Skin Damage Models in Experimental Animals

Abstract

The invention discloses a light irradiation device used for establishment of an experimental animal skin injury model. The light irradiation device comprises a box body. The top end of the box body is provided with an upper cover device, and the upper cover device comprises an upper cover plate. Fixing pressing plate troughs are installed on both sides of a fixing trough support. Fixing pressing plates are installed in grooves of the fixing pressing plate troughs, and the fixing pressing plates are provided with light control holes. According to the light irradiation device, the side walls of box body are provided with height adjusting holes, and the height between a light source and animals subjected to an experiment can be adjusted through the height adjusting holes; the positions of light source transmission can be controlled through light transmission holes formed in a separation plate; the animals are fixed by adjusting the fixing pressing plates 43, and the positions of light irradiation animal skin injuries are adjusted by adjusting the light control holes 44 in the fixing pressing plates 43 to protect other parts of the animals subjected to the experiment from injuries; the light source in a lamp holder is arranged in the upper cover device, so that ultraviolet / infrared lamps with different wave lengths or high energy ray sources with different wave lengths are replaced or used simultaneously according to the experiment needs.

Description

technical field [0001] The invention relates to the field of medical experiment devices, in particular to a light irradiation device for establishing experimental animal skin damage models. Background technique [0002] In order to verify the moisturizing, whitening, anti-wrinkle, anti-ultraviolet or other light damage effects of the experimental materials on the skin, the materials to be verified will be tested in the laboratory with experimental animals such as nude mice, rats, guinea pigs, and experimental miniature pigs. Skin injury and anti-injury experiments are used to obtain preliminary safety and efficacy data as the basis for further development. Therefore, the establishment of animal skin injury models during the experiment is particularly important. [0003] It is very common to use ultraviolet light to establish skin injury models. Generally, after fixing the animals by themselves, they are exposed to ultraviolet light to establish models, or directly put animal...

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Problems solved by technology

[0004] 1. All the animals used in the experiment are exposed to ultraviolet light and other damaging light. If they are not fixed, the animals will pass the time of building models in the ultraviolet light box in different attitudes. In this way, it is difficult to ensure that during the daily experiment, it is difficult to observe of the skin area receives the same amount of light every day

[0005] 2. The whole body of the experimental animals is exposed to the damaging light. If the animal is fixed, the animal cannot have self-protection behavior, so that the eyes and other vulnerable parts of the body will be exposed to the damaging light. During the long-term experiment, the damage to the animal body will be very serious. Serious, does not meet the requirements of the ethical guidelines for animal experiments

[0006] 3. The method of fixing the animal is inappropriate, if the fixation is too tight, the animal may suffocate, the extremities are congested, and the animal is restless, screaming or injured, which is not good for long-term experiments; if the fixation is too loose, the area of ​​the animal's skin exposed to ultraviolet light will not be fixed. Or the fixed skin observation area is affected by the inhomogeneity of ultraviolet illumination, which brings troubles to the controllability of the experimental process and the reliability of the experimental results

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