Release detection method of aniracetam sustained release tablet

A detection method and technology of Aniracetam are applied in the field of drug release detection of Aniracetam sustained-release tablets, and achieve the effects of being convenient for large-scale industrial production, large application value and simple operation of the method.

Inactive Publication Date: 2015-12-16
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no good systematic drug release detection method for Aniracetam sustained-release tablets

Method used

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  • Release detection method of aniracetam sustained release tablet
  • Release detection method of aniracetam sustained release tablet
  • Release detection method of aniracetam sustained release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Drug release detection method

[0031] A drug release detection method for Aniracetam sustained-release tablets

[0032] (1) Selection of maximum absorption wavelength

[0033] Accurately weigh 5.02mg of Aniracetam reference substance, put it in a 50ml volumetric flask, add a small amount of ethanol to dissolve it, dilute it to the mark with hydrochloric acid solution (9→1000), draw 1.0mL into a 100mL volumetric flask, and dissolve it with hydrochloric acid solution (9→1000). 1000) diluted to scale, according to "Chinese Pharmacopoeia" 2010 edition appendix IVA ultraviolet spectrophotometry, carry out ultraviolet scanning, the result has maximum absorption at 282nm, so the selection detection wavelength is 282nm. See figure 1 .

[0034] (2) The influence of rotational speed on the release rate of the main drug

[0035] Get this product, according to the release assay method, adopt the release assay method (Chinese Pharmacopoeia 2010 version two appendix XD second me...

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Abstract

Belonging to the technical field of drugs, the invention discloses a release detection method of an aniracetam sustained release tablet. The release detection method of the aniracetam sustained release tablet comprises the steps of: 1) in vitro dissolution rate test of the aniracetam sustained release tablet; 2) determination of in vivo blood concentration; and 3) in vitro-in vivo correlation analysis. The invention constructs in vitro evaluation model simulating the in vivo, establishes an in vitro-in vivo correlation multi-criteria evaluation technology, increases new evaluation indexes, and establishes a new detection method, better explains advantages of the prescription, establishes an evaluation technique suitable for drugs with too quick prototype drug release, and provides the basis and guidance for study of the drug in future.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a method for detecting the drug release of Aniracetam sustained-release tablets. Background technique [0002] As an important drug for the treatment of senile dementia, Aniracetam has different effects on vascular dementia with mild to moderate learning, memory and cognitive dysfunction, Alzheimer's disease, and mild to moderate cognition after stroke. It has a more obvious therapeutic effect on behavior disorders and benign memory disorders in middle-aged and elderly people. At present, the commercially available dosage forms of Aniracetam mainly include tablets, granules and dispersible tablets, most of which are conventional dosage forms, all of which have defects such as large dosage, short half-life, and many times of taking medicine. Patient takes medicine to bring a lot of inconveniences. [0003] Sustained-release preparations refer to the slow and non-constant relea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/33G01N30/02G01N33/15
Inventor 贡济宇蔡广知许大艳李连坤杨建龙
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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