Sodium bicarbonate injection double-layer aseptic vertical bag package system and preparation method thereof

Abstract

The invention discloses a sodium bicarbonate injection double-layer aseptic vertical bag package system and a preparation method thereof; the package system comprises the following structures: a polypropylene vertical inner bag, and a medicine cavity used for containing sodium bicarbonate injection soup and carbon dioxide gas is arranged in the inner bag; an isolation protection bag, wherein a seal cavity used for containing the polypropylene vertical inner bag is arranged in the isolation protection bag. The polypropylene vertical inner bag is contained in the seal cavity, and the seal cavity is a vacuum seal cavity. The vacuum seal cavity is formed in the isolation protection bag, and the polypropylene vertical inner bag is contained in the vacuum seal cavity, thus preventing gas penetrating problems, and gas cannot be enter the seal cavity; bag deformation or bag damages caused by gas expansion in high temperature disinfection can be prevented, thus improving quality safety of the sodium bicarbonate injection vertical bag package system, improving heat penetrating force in the disinfection process, and improving disinfection effect.

Description

technical field [0001] The invention relates to the field of medical packaging, in particular to a sodium bicarbonate injection stand-up pouch packaging system and a preparation method thereof. Background technique [0002] The infusion packaging has gone through glass bottles and plastic bottles. The production from bottle making to filling and sealing is basically completed in the same clean workshop, and clinical use has achieved progress from fully open to semi-open. In order to avoid secondary pollution and realize fully airtight infusion, the infusion with plastic bag packaging that can shrink automatically has been researched and designed. Currently the most widely used are non-PVC co-extruded film bags and polypropylene stand-up bags. [0003] With the development of clinical application of infusion, the varieties of infusion are no longer just simple saline and glucose. Sodium bicarbonate injections are also more and more developed and widely used in clinical prac...

AI Technical Summary

Problems solved by technology

But the glass bottle packaging has the following shortcomings: (1) the quality is fragile and fragile, and the existence of this deficiency brings great inconvenience to the clinical use of the glass bottle packaging; (2) air must be introduced during infusion. There may be secondary pollution and changes in the properties of the glass bottle packaging during the infusion process; (3) the surface of the soda-lime glass is easily corroded and peeled off, etc., with the volatilization of carbon dioxide in the glass bottle packaging, the The alkalinity gradually increases, which makes the surface of the soda-lime glass vulnerable to corrosion and peeling off, which may seriously endanger the safety of infusion and patients

However, this structure has the following problems in the subsequent sterilization process: (1) If the inner bag is sterilized at high temperature first, and then the outer bag with barrier properties is added

In this case, on the one hand, it is easy to cause the air in the inner bag to leak out during high temperature sterilization; on the other hand, the outer bag is sealed after sterilization, and the inner bag is no longer sterile

Moreover, because carbon dioxide gas is filled between the inner and outer bags, it is difficult to seal the outer bag of this infusion bag, which is easy to cause the bag body to break, and it is difficult to ensure product safety.

(2) If the overall high-temperature sterilization of the infusion package is performed after adding an outer bag with barrier properties, the existence of carbon dioxide gas may prevent heat penetration, resulting in uneven sterilization; moreover, the gas may expand during heating, which is easy to Cause the bag to break or deform

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