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Improving adhesive properties

A technology of adhesive performance and viscosity, applied in polymer adhesive additives, adhesives, drug combinations, etc., can solve problems such as reducing the efficacy of active substances

Active Publication Date: 2015-12-30
AVERY DENNISON CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is undesirable because crystallization creates unpredictable changes in the release rate of the active and reduces the potency of the active

Method used

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  • Improving adhesive properties
  • Improving adhesive properties
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[0095] An evaluation was undertaken to evaluate several adhesive compositions in accordance with the present subject matter. Materials used for the adhesive composition are as follows:

[0096]Adhesive: T2650 (Avery Dennison), styrene-isoprene hot melt adhesive;

[0097] Absorbent: AQUASORBA 500 (Ashland), sodium carboxymethyl cellulose;

[0098] PVP: LUVITECK17 (BASF), a soluble PVP homopolymer with an average molecular weight of 9 kDa;

[0099] Drug: ibuprofen (BASF), USP-grade

[0100] Carrier: Propylene Glycol

[0101] Various compositions were prepared. For each composition, a comparative composition was prepared.

[0102] For each resulting set of compositions, the following measurements were made: (i) adhesion to polyethylene, ie "peel value", (ii) tack value, (iii) active release after 2 hours, ie "Elution 2 hours", (iv) active release after 6 hours, ie "6 hours elution", and (v) fluid handling capability, ie "FHC".

[0103] Specifically, samples were prepared a...

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Abstract

Various adhesive compositions are described which may optionally comprise one or more active agents such as pharmaceutical agents. The incorporation of one or more absorbents in combination with one or more crystallization inhibitors improves adhesive characteristics of the compositions. Also described are related methods of improving adhesive characteristics of adhesive compositions with the use of a combination of absorbent and inhibitor. Also described are related methods of using the compositions and articles incorporating such compositions.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to US Provisional Patent Application No. 61 / 778,606, filed March 13, 2013, which is incorporated herein by reference in its entirety. technical field [0003] This subject is concerned with improving adhesive properties. In certain aspects, the present subject matter relates to improving the adhesive properties of adhesive compositions that release one or more active agents. The subject matter specifically relates to medical adhesives comprising one or more pharmaceutically active agents. Background technique [0004] Adhesive compositions are known to incorporate one or more active agents for release upon placement in contact with human skin tissue. A carrier or solvent is used to dissolve or suspend one or more active agents therein and to introduce the actives into the binder. Absorbents can be used in compositions to absorb, retain, or transport moisture or aqueous agents that may...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/58A61L24/00C09J11/08
CPCA61L15/585A61L24/001A61L24/0094C09J11/08A61K31/192C09J153/02C08G2170/20A61K9/7053C08L1/286C08L39/06A61P29/00A61L24/0015A61L24/06A61L24/08A61L2300/21
Inventor N·卡蒂
Owner AVERY DENNISON CORP