Nitraria sibirica fruit total flavonoid extract and preparation method of nitraria sibirica fruit total flavonoid extract

An extraction method and technology of Nitraria japonica, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of high extraction cost, incomplete recovery of organic solvent, low yield of flavonoids, etc., and achieve the effect of simple operation

Inactive Publication Date: 2016-01-06
青海花赐生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the general way of preparing the total flavonoids extract of Nitraria japonica in the prior art is simple ethanol reflux extraction, the extra

Method used

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  • Nitraria sibirica fruit total flavonoid extract and preparation method of nitraria sibirica fruit total flavonoid extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Cleaning: Select 10kg of mature Nitraria berries, filter out the sediment, and wash with clean water;

[0041] 2. Drying: Dry the cleaned Nitraria fruit at a low temperature of 15°C for 15 hours;

[0042] 3, crushing: the Nitraria fruit obtained in step 2 is ultrafinely pulverized to obtain Nitraria powder;

[0043] 4. Extraction: Add 5 times the amount of 70% ethanol to the Nitraria powder obtained in step 3 for ultrasonic extraction for 1 hour, stir with a stirrer during this period, obtain filtrate I and filter residue I after filtration, and use filter residue I again for 7 times A large amount of 70% ethanol was refluxed and extracted for 1 h, filtrate II and filter residue II were obtained after filtration, filtrate I and filtrate II were combined, concentrated under reduced pressure to obtain the crude extraction part of total flavonoids of Nitraria japonica;

[0044] 5. Purification: Pack the pretreated polyamide into a column by wet method, take the above c...

Embodiment 2

[0047]1. Cleaning: Select 10kg of mature Nitraria berries, filter out the sediment, and wash with clean water;

[0048] 2. Drying: Dry the cleaned Nitraria fruit at a low temperature of 20°C for 15 hours;

[0049] 3, crushing: the Nitraria fruit obtained in step 2 is ultrafinely pulverized to obtain Nitraria powder;

[0050] 4. Extraction: Add 8 times the amount of 70% ethanol to the Nitraria powder obtained in step 3 for ultrasonic extraction for 1 hour, stir with a stirrer during this period, obtain filtrate I and filter residue I after filtration, and use filter residue I again for 6 times A large amount of 80% ethanol was refluxed and extracted for 1 hour, and the filtrate II and filter residue II were obtained after filtration, the filtrate I and the filtrate II were combined, and concentrated under reduced pressure to obtain the crude extraction part of the total flavonoids of Nitraria japonica;

[0051] 5. Purification: Wet-pack the pretreated polyamide column, take th...

Embodiment 3

[0054] 1. Cleaning: Select 10kg of mature Nitraria berries, filter out the sediment, and wash with clean water;

[0055] 2. Drying: Dry the cleaned Nitraria fruit at a low temperature of 15°C for 20 hours;

[0056] 3, crushing: the Nitraria fruit obtained in step 2 is ultrafinely pulverized to obtain Nitraria powder;

[0057] 4. Extraction: Add 5 times the amount of 70% ethanol to the Nitraria powder obtained in step 3 for ultrasonic extraction for 1.5 hours, stir with a stirrer during this period, obtain filtrate I and filter residue I after filtration, and use filter residue I again for 7 Doubling the amount of 65% ethanol for reflux extraction for 1.5 h, after filtration to obtain filtrate II and filter residue II, combine filtrate I and filtrate II, and concentrate under reduced pressure to obtain the crude extract of total flavonoids from Nitraria japonica;

[0058] 5. Purification: Wet packed the pretreated Nylon polyamide column, took the above crude extract and loaded...

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Abstract

The invention relates to a nitraria sibirica fruit total flavonoid extract and a preparation method of the nitraria sibirica fruit total flavonoid extract. Nitraria sibirica fruit obtained by the preparation method of cleaning, drying, crushing, impurity removal, extraction, purification and the like has the functions of delaying senescence, reducing the blood glucose, reducing blood fat and realizing the health care. Meanwhile, the preparation method of the nitraria sibirica fruit total flavonoid extract has the advantages that the process is simple; the operation is easy; the yield is higher; the quality is good; the industrial production process is favorably realized.

Description

technical field [0001] The invention relates to the field of plant extracts, in particular to an extract of Nitraria japonica, which has the functions of delaying aging, lowering blood sugar, and lowering blood fat, and a preparation method thereof. Background technique [0002] Nitraria tangutoum Bor (Nitraria tangutoum Bor), also known as sour fat, is known as "wild cherry". It is a small deciduous shrub of the genus Nitearia in the family Zygophyllceae. Inner Mongolia, Ningxia, Gansu, Xinjiang, Qinghai and other places. Nitraria has a high medicinal value and has a long history of being used as medicine in the minority areas of Northwest China. Nitraria, the ancient Chinese names are Dongjin and Shapengmi, and the common name is sand cherry. "Supplements to Materia Medica": "Dongjin, sweet and flat in taste, non-toxic, nourishing qi and lightening body, long-term use without hunger, and strengthening muscles and bones." According to the "Compendium of Materia Medica", ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/06A61P39/06A61P9/12A61P3/10
Inventor 刘洪智马菊秀雷占兰
Owner 青海花赐生物科技有限公司
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