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Compositions for use in cartilage breakdown

A composition and nutritional composition technology, applied in the direction of drug combination, bone disease, plant raw materials, etc.

Inactive Publication Date: 2016-01-13
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, it is an object of the present invention to provide a composition for improving joint health by preventing or treating cartilage destruction, and solving the above-mentioned problems of the prior art in terms of side effects such as gastrointestinal and / or cardiovascular risks

Method used

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  • Compositions for use in cartilage breakdown
  • Compositions for use in cartilage breakdown
  • Compositions for use in cartilage breakdown

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0209] Example 1 - In vitro studies - bovine primary chondrocytes in alginate beads

[0210] Materials and methods

[0211] Oleuropein. Essentially pure oleuropein (>98%) was purchased from Extrasynthese (GENAY, France).

[0212] Hydroxytyrosol. Substantially pure hydroxytyrosol (>98%) was purchased from Extrasynthese (GENAY, France). Metabolites of oleuropein.

[0213] quercetin. Substantially pure quercetin (>97%) was purchased from HWIA Analytik GmbH (Ruelzheim, Germany). Metabolites of rutin.

[0214] rutin. Essentially pure rutin (>94%) was purchased from Sigma-Aldrich (Buchs, Switzerland).

[0215] Curcumin. Essentially pure rutin (>70%) was purchased from Sigma-Aldrich (Buchs, Switzerland).

[0216] cell culture

[0217] Wash the hooves of young cattle to remove the dirt. The skin is removed from the hoof. Open the joint laterally. Transect the intra-articular ligament. Wash the opened joint with phosphate-buffered saline. With a scalpel blade, carti...

Embodiment 2

[0244] Example 2 In Vivo Study - Spontaneously Developed Osteoarthritis in Hartley Guinea Pigs

[0245] animals and treatment

[0246] Sixty-five 3-week-old male Hartley guinea pigs were obtained from Charles River Laboratories (Paris). Five animals were housed in one solid bottom cage on standard guinea pig chow containing vitamin C (1 mg / g) and vitamin D3 (3.4 IU / g), water was available ad libitum. All animals were allowed to acclimatize in house conditions for one week prior to administration of oleuropein, rutin and / or curcumin. PVC pipes lead into the cages to improve housing conditions and reduce stress.

[0247] One week later, 4-week-old male Hartley guinea pigs were randomly divided into experimental groups:

[0248] - Group A (n=15) received daily doses of oleuropein for 31 weeks

[0249] - Group B (n=15) received a standard diet (control) during 31 weeks;

[0250] - Group C (n=15) received daily doses of rutin for 31 weeks

[0251] - Group D (n=15) received ...

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PUM

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Abstract

The present invention relates to use of a composition comprising oleuropein and / or hydroxytyrosol for maintenance of joint health or prevention or treatment of joint disorders. In particular, the invention relates to oleuropein for use to prevent or treat cartilage breakdown.

Description

technical field [0001] The present invention relates to joint health, in particular the present invention relates to the use of a composition comprising oleuropein and / or hydroxytyrosol for preventing or treating cartilage destruction or maintaining joint health. Background technique [0002] Osteoarthritis (OA) is a high-morbidity disease with significant socioeconomic impact. It is a degenerative disease of the articular cartilage in the joints and is the most common form of arthritis, affecting 10% of the adult population. OA is the leading cause of disability and health care spending in older adults worldwide. [0003] Gradual destruction and loss of articular cartilage is the main pathological feature, accompanied by other joint structural changes, such as synovial hyperplasia, sclerosis and thickness of subchondral bone, osteophyte formation at joint margins, ligament laxity and muscle atrophy, all These all lead to the clinical symptoms of OA. These symptoms includ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K31/12A61K31/7048A61K45/06A61P19/02
CPCA61K36/76A61K36/82A61K36/88A61K36/9066A61K36/9068A61K45/06A61K31/12A61K36/185A61K36/28A61K36/324A61K36/38A61K36/53A61K36/71A61K31/7048A61P19/02A61P29/00A61P43/00Y02A50/30A61K2300/00A61K36/74
Inventor M·N·奥卡亚达F·门布雷兹E·奥佛德 卡万
Owner SOC DES PROD NESTLE SA